Action Potential Initiation in Neocortical Inhibitory Interneurons
文献类型：期刊论文
| 作者 | Li, T ; Tian, CP ; Scalmani, P ; Frassoni, C ; Mantegazza, M ; Wang, YH ; Yang, MP ; Wu, S ; Shu, YS |
| 刊名 | PLOS BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:9页码:e1001944-e1001944 |
| ISSN号 | 1545-7885 |
| 关键词 | CEREBELLAR PURKINJE NEURONS NEONATAL-INFANTILE SEIZURES SEVERE MYOCLONIC EPILEPSY DE-NOVO MUTATIONS SODIUM-CHANNEL PYRAMIDAL NEURONS GABAERGIC INTERNEURONS DRAVET SYNDROME ION CHANNELS MOUSE MODEL |
| 通讯作者 | Li, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.,yousheng@bnu.edu.cn |
| 英文摘要 | Action potential (AP) generation in inhibitory interneurons is critical for cortical excitation-inhibition balance and information processing. However, it remains unclear what determines AP initiation in different interneurons. We focused on two predominant interneuron types in neocortex: parvalbumin (PV)-and somatostatin (SST)-expressing neurons. Patch-clamp recording from mouse prefrontal cortical slices showed that axonal but not somatic Na+ channels exhibit different voltage-dependent properties. The minimal activation voltage of axonal channels in SST was substantially higher (similar to 7mV) than in PV cells, consistent with differences in AP thresholds. A more mixed distribution of high-and low-threshold channel subtypes at the axon initial segment (AIS) of SST cells may lead to these differences. Surprisingly, Na(V)1.2 was found accumulated at AIS of SST but not PV cells; reducing Na(V)1.2-mediated currents in interneurons promoted recurrent network activity. Together, our results reveal the molecular identity of axonal Na+ channels in interneurons and their contribution to AP generation and regulation of network activity. |
| 学科主题 | Biochemistry & Molecular Biology ; Biology |
| 资助信息 | 973 Program [2011CBA00400]; National Natural Science Foundation of China Project [31025012]; Hundreds of Talents Program from Chinese Academy of Sciences; PICS-NavROLE; European Union [602531 "DESIRE''] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2644]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, T,Tian, CP,Scalmani, P,et al. Action Potential Initiation in Neocortical Inhibitory Interneurons[J]. PLOS BIOLOGY,2014,12(9):e1001944-e1001944. |
| APA | Li, T.,Tian, CP.,Scalmani, P.,Frassoni, C.,Mantegazza, M.,...&Shu, YS.(2014).Action Potential Initiation in Neocortical Inhibitory Interneurons.PLOS BIOLOGY,12(9),e1001944-e1001944. |
| MLA | Li, T,et al."Action Potential Initiation in Neocortical Inhibitory Interneurons".PLOS BIOLOGY 12.9(2014):e1001944-e1001944. |
入库方式： OAI收割
来源：上海神经科学研究所
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