Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila
文献类型：期刊论文
| 作者 | Liu, H ; Zhou, BY ; Yan, WJ ; Lei, ZC ; Zhao, XL ; Zhang, K ; Guo, AK |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 40期号:5页码:2744-2754 |
| 关键词 | VISUAL PROJECTION NEURONS BLOOD-BRAIN-BARRIER ANTENNAL LOBE IN-SITU CALCIUM OSCILLATIONS LOCAL INTERNEURONS MOSAIC ANALYSIS SYSTEM TRANSFORMATION PLASTICITY |
| ISSN号 | 0953-816X |
| 通讯作者 | Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai, Peoples R China.,akguo@ion.ac.cn |
| 英文摘要 | Astrocyte-like glial cells are abundant in the central nervous system of adult Drosophila and exhibit morphology similar to astrocytes of mammals. Previous evidence has shown that astrocyte-like glial cells are strongly associated with synapses in the antennal lobe (AL), the first relay of the olfactory system, where olfactory receptor neurons (ORNs) transmit information into projection neurons (PNs). However, the function of astrocyte-like glia in the AL remains obscure. In this study, using in vivo calcium imaging, we found that astrocyte-like glial cells exhibited spontaneous microdomain calcium elevations. Using simultaneous manipulation of glial activity and monitoring of neuronal function, we found that the astrocyte-like glial activation, but not ensheathing glial activation, could inhibit odor-evoked responses of PNs. Ensheathing glial cells are another subtype of glia, and are of functional importance in the AL. Electrophysiological experiments indicated that astrocyte-like glial activation decreased the amplitude and slope of excitatory postsynaptic potentials evoked through electrical stimulation of the antennal nerve. These results suggest that astrocyte-like glial cells may regulate olfactory processing through negative regulation of ORN-PN synaptic strength. Beyond the antennal lobe we observed astrocyte-like glial spontaneous calcium activities in the ventromedial protocerebrum, indicating that astrocyte-like glial spontaneous calcium elevations might be general in the adult fly brain. Overall, our study demonstrates a new function for astrocyte-like glial cells in the physiological modulation of olfactory information transmission, possibly through regulating ORN-PN synapse strength. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CBA00400]; National Science Foundation of China [30921064, 90820008, 31130027]; Chinese Academy of Sciences [XDB02040100] |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2645]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, H,Zhou, BY,Yan, WJ,et al. Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2014,40(5):2744-2754. |
| APA | Liu, H.,Zhou, BY.,Yan, WJ.,Lei, ZC.,Zhao, XL.,...&Guo, AK.(2014).Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila.EUROPEAN JOURNAL OF NEUROSCIENCE,40(5),2744-2754. |
| MLA | Liu, H,et al."Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila".EUROPEAN JOURNAL OF NEUROSCIENCE 40.5(2014):2744-2754. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。