MeCP2: multifaceted roles in gene regulation and neural development
文献类型：期刊论文
| 作者 | Cheng, TL ; Qiu, ZL |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:4页码:601-609 |
| 关键词 | CPG-BINDING PROTEIN RETT-SYNDROME PHENOTYPES DNA METHYLATION MOUSE MODEL TRANSCRIPTIONAL REPRESSION DEPENDENT PHOSPHORYLATION CHROMOSOMAL PROTEIN BDNF TRANSCRIPTION DENDRITIC GROWTH NONCODING RNAS |
| ISSN号 | 1673-7067 |
| 通讯作者 | Cheng, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,tlcheng@ion.ac.cn |
| 英文摘要 | Methyl-CpG-binding protein 2 (MeCP2) is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially recognized as a transcriptional repressor, MeCP2 has been studied extensively and its functions have been expanded dramatically in the past two decades. Recently, it was found to be involved in gene regulation at the post-transcriptional level. MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex. In addition to its multifaceted functions, MeCP2 is remarkably modulated by posttranslational modifications such as phosphorylation, SUMOylation, and acetylation, providing more regulatory dimensions to its functions. The role of MeCP2 in the central nervous system has been studied extensively, from neurons to glia. Future investigations combining molecular, cellular, and physiological methods are necessary for defining the roles of MeCP2 in the brain and developing efficient treatments for MeCP2-related brain disorders. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Development Program of China [2011CBA00400]; Strategic Priority Research Program of the Chinese Academy of Science, China [XDB02050400] |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2650]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Cheng, TL,Qiu, ZL. MeCP2: multifaceted roles in gene regulation and neural development[J]. NEUROSCIENCE BULLETIN,2014,30(4):601-609. |
| APA | Cheng, TL,&Qiu, ZL.(2014).MeCP2: multifaceted roles in gene regulation and neural development.NEUROSCIENCE BULLETIN,30(4),601-609. |
| MLA | Cheng, TL,et al."MeCP2: multifaceted roles in gene regulation and neural development".NEUROSCIENCE BULLETIN 30.4(2014):601-609. |
入库方式： OAI收割
来源：上海神经科学研究所
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