Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation
文献类型：期刊论文
| 作者 | Liu, JN ; Liu, Y ; Bu, WB ; Bu, JW ; Sun, Y ; Du, JL ; Shi, JL |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2014 |
| 卷号 | 136期号:27页码:9701-9709 |
| 关键词 | LANTHANIDE-DOPED NANOPARTICLES TUMOR HYPOXIA FLUORESCENCE PROBE UPCONVERTING NANOPARTICLES NAYF4 NANOCRYSTALS DRUG-DELIVERY LIVE CELLS OXYGEN THERAPY CANCER |
| ISSN号 | 0002-7863 |
| 通讯作者 | Bu, WB (reprint author), Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China.,wbbu@mail.sic.ac.cn ; jlshi@mail.sic.ac.cn |
| 英文摘要 | Hypoxia is a distinct feature of malignant solid tumors, which is a possible causative factor for the serious resistance to chemo- and radiotherapy or the development of invasion and metastasis. The exploration of nanosensors with the capabilities like the accurate diagnosis of hypoxic level will be helpful to estimate the malignant degree of tumor and subsequently implement more effective personalized treatment. Here, we report the design and synthesis of nanosensors that can selectively and reversibly detect the level of hypoxia both in vitro and in vivo. The designed nanosensor is composed of two main moieties: oxygen indicator [Ru(dpp)(3)]Cl-2+(2) or detection of hypoxia and upconversion nanoparticles for offering the excitation light of [Ru(dpp)(3)]Cl-2+(2) by upconversion process under 980 nm exposure. The results show that the nanosensors can reversibly become quenched or luminescent under hyperoxic or hypoxic conditions, respectively. Compared with free [Ru(dpp)(3)]Cl-2+(2), the designed nanosensors exhibit enhanced sensitivity for the detection of oxygen in hypoxic regions. More attractively, the nanosensors can image hypoxic regions with high penetration depth because the absorption and emission wavelength are within the NIR and far-red region, respectively. Most importantly, nanosensors display a high selectivity for detection of relevant oxygen changes in cells and zebrafish. |
| 学科主题 | Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [51372260, 51132009]; Shanghai Rising-Star Program [12QH1402500]; Nano special program of the Science and Technology Commission of Shanghai [11 nm0505000]; Shanghai Yangfan Program [14YF1406400]; Shanghai Pujiang Program [13PJ1401600] |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2654]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, JN,Liu, Y,Bu, WB,et al. Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(27):9701-9709. |
| APA | Liu, JN.,Liu, Y.,Bu, WB.,Bu, JW.,Sun, Y.,...&Shi, JL.(2014).Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(27),9701-9709. |
| MLA | Liu, JN,et al."Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.27(2014):9701-9709. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。