中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats

文献类型:期刊论文

作者Li, J ; Tang, YH ; Wang, YT ; Tang, RB ; Jiang, WF ; Yang, GY ; Gao, WQ
刊名STEM CELL REPORTS
出版日期2014
卷号3期号:1页码:1111-1111
关键词STEM-CELLS IN-VIVO POPULATION MECHANISMS MATURATION DEFICITS THERAPY SCIENCE INJURY
ISSN号2213-6711
通讯作者Yang, GY (reprint author), Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China.,gyyang0626@gmail.com ; gao.weiqiang@sjtu.edu.cn
英文摘要The concept of the "neurovascular unit,'' emphasizing the interactions between neural and vascular components in the brain, raised the notion that neural progenitor cell (NPC) transplantation therapy aimed at neural repair may be insufficient for the treatment of ischemic stroke. Here, we demonstrate that enhanced neurovascular recovery via cotransplantation of NPCs and embryonic stem cell-derived vascular progenitor cells (VPCs) in a rat stroke model is correlated with improved functional recovery after stroke. We found that cotransplantation promoted the survival, migration, differentiation, and maturation of neuronal and vascular cells derived from the cotransplanted progenitors. Furthermore, it triggered an increased generation of VEGF-, BDNF-, and IGF1-expressing neural cells derived from the grafted NPCs. Consistently, compared with transplantation of NPCs alone, cotransplantation more effectively improved the neurobehavioral deficits and attenuated the infarct volume. Thus, cotransplantation of NPCs and VPCs represents a more effective therapeutic strategy for the treatment of stroke than transplantation of NPCs alone.
学科主题Cell & Tissue Engineering ; Cell Biology
收录类别SCI
资助信息Chinese Ministry of Science and Technology [2012CB966800, 2013CB945600, 2012CB967903, 2011CB504405]; National Natural Science Foundation of China [81130038, 81372189, 81302235, 81070939]; Key Discipline and Specialty Foundation of Shanghai Health Bureau; Science and Technology Commission of Shanghai Municipality [10JC1408100]; Shanghai Education Committee Key Discipline and Specialty Foundation [J50208]; K.C. Wong Foundation; China Postdoctoral Science Foundation [20110490737]
语种英语
公开日期2014-12-15
源URL[http://ir.sibs.ac.cn/handle/331001/2655]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Li, J,Tang, YH,Wang, YT,et al. Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats[J]. STEM CELL REPORTS,2014,3(1):1111-1111.
APA Li, J.,Tang, YH.,Wang, YT.,Tang, RB.,Jiang, WF.,...&Gao, WQ.(2014).Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats.STEM CELL REPORTS,3(1),1111-1111.
MLA Li, J,et al."Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats".STEM CELL REPORTS 3.1(2014):1111-1111.

入库方式: OAI收割

来源:上海神经科学研究所

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