Regulation of Action Potential Waveforms by Axonal GABA(A) Receptors in Cortical Pyramidal Neurons
文献类型：期刊论文
| 作者 | Xia, Y ; Zhao, Y ; Yang, MP ; Zeng, SQ ; Shu, YS |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:6页码:e100968-e100968 |
| 关键词 | PRESYNAPTIC IONOTROPIC RECEPTORS HIPPOCAMPAL MOSSY FIBERS TRANSMITTER RELEASE INHIBITORY SYNAPSES EXCITATORY ACTIONS INITIAL SEGMENT CELLS CHANNELS CORTEX MODULATION |
| ISSN号 | 1932-6203 |
| 通讯作者 | Zeng, SQ (reprint author), Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China.,sqzeng@hust.edu.cn ; yousheng@bnu.edu.cn |
| 英文摘要 | GABA(A) receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABA(A) receptors at the axon are still poorly understood. By recording from the cut end (bleb) of the main axon trunk of layer -5 pyramidal neurons in prefrontal cortical slices, we found that currents evoked by GABA iontophoresis could be blocked by picrotoxin, indicating the expression of GABA(A) receptors in axons. Stationary noise analysis revealed that single-channel properties of axonal GABA(A) receptors were similar to those of somatic receptors. Perforated patch recording with gramicidin revealed that the reversal potential of the GABA response was more negative than the resting membrane potential at the axon trunk, suggesting that GABA may hyperpolarize the axonal membrane potential. Further experiments demonstrated that the activation of axonal GABA(A) receptors regulated the amplitude and duration of action potentials (APs) and decreased the AP-induced Ca2+ transients at the axon. Together, our results indicate that the waveform of axonal APs and the downstream Ca2+ signals are modulated by axonal GABA(A) receptors. |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 资助信息 | 973 Program [2011CBA00400]; National Natural Science Foundation of China Project [31025012, 81327802]; Chinese Academy of Sciences |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2657]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xia, Y,Zhao, Y,Yang, MP,et al. Regulation of Action Potential Waveforms by Axonal GABA(A) Receptors in Cortical Pyramidal Neurons[J]. PLOS ONE,2014,9(6):e100968-e100968. |
| APA | Xia, Y,Zhao, Y,Yang, MP,Zeng, SQ,&Shu, YS.(2014).Regulation of Action Potential Waveforms by Axonal GABA(A) Receptors in Cortical Pyramidal Neurons.PLOS ONE,9(6),e100968-e100968. |
| MLA | Xia, Y,et al."Regulation of Action Potential Waveforms by Axonal GABA(A) Receptors in Cortical Pyramidal Neurons".PLOS ONE 9.6(2014):e100968-e100968. |
入库方式： OAI收割
来源：上海神经科学研究所
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