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The complete genome sequence of a Neanderthal from the Altai Mountains
文献类型：期刊论文
| 作者 | Pruefer, Kay1; Racimo, Fernando2; Patterson, Nick3; Jay, Flora2; Sankararaman, Sriram3,4; Sawyer, Susanna1; Heinze, Anja1; Renaud, Gabriel1; Sudmant, Peter H.5; de Filippo, Cesare1 |
| 刊名 | NATURE
 |
| 出版日期 | 2014-01-02 |
| 卷号 | 505期号:7481页码:43-+ |
| ISSN号 | 0028-0836 |
| 文献子类 | Article |
| 英文摘要 | We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans. |
| WOS关键词 | ANCIENT DNA ; POPULATION HISTORY ; MEZMAISKAYA CAVE ; HUMAN-EVOLUTION ; GREAT APE ; ADMIXTURE ; ANCESTRY ; HOMININ ; SIBERIA ; ASIA |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000329163300020 |
| 资助机构 | NSF [1032255]; NIH [GM100233, HG002385, R01-GM40282]; National Genome Research Institute (NHGRI) [HG006283]; Harvard University Science of the Human Past Program; HHMI International Student Fellowship; Paul G. Allen Family Foundation; Presidential Innovation Fund of the Max Planck Society |
| 公开日期 | 2014-12-12 |
| 源URL | [http://119.78.100.205/handle/311034/5190]  |
| 专题 | 古脊椎动物与古人类研究所_古人类及旧石器研究室 |
| 通讯作者 | Slatkin, M (reprint author), Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA. |
| 作者单位 | 1.Max Planck Inst Evolutionare Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany 2.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 3.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 4.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 5.Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA 6.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 7.NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA 8.NHGRI, NIH Intramural Sequencing Ctr, NIH, Bethesda, MD 20892 USA 9.Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA 10.Max F Perutz Labs, Math & Biosci Grp, Campus Vienna Bioctr 5, A-1030 Vienna, Austria |
| 推荐引用方式 GB/T 7714 | Pruefer, Kay,Racimo, Fernando,Patterson, Nick,et al. The complete genome sequence of a Neanderthal from the Altai Mountains[J]. NATURE,2014,505(7481):43-+. |
| APA | Pruefer, Kay.,Racimo, Fernando.,Patterson, Nick.,Jay, Flora.,Sankararaman, Sriram.,...&Slatkin, M .(2014).The complete genome sequence of a Neanderthal from the Altai Mountains.NATURE,505(7481),43-+. |
| MLA | Pruefer, Kay,et al."The complete genome sequence of a Neanderthal from the Altai Mountains".NATURE 505.7481(2014):43-+. |
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来源：古脊椎动物与古人类研究所
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