A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo
文献类型：期刊论文
| 作者 | Xu J(徐健)1,2,3 ; Li Q(李欠)1,2; Yue Y(岳莹)1,2; Guo Y(郭勇)1,2; Shao SJ(邵士俊)1,2; Shao SJ(邵士俊)
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| 刊名 | Biosensors and Bioelectronics
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| 出版日期 | 2014 |
| 卷号 | 56页码:58-63 |
| 关键词 | N-alkylpyridinium substituted BODIPY derivatives Water-soluble fluorescent probe Fluorescent sensor H2O2 In vitro and in vivo imaging |
| ISSN号 | 0956-5663 |
| 通讯作者 | 邵士俊 |
| 英文摘要 | A type of BODIPY derivatives was designed and synthesized by the N-alkylation reaction of meso-(4-pyridinyl)-substituted BODIPY. The water-solubility of entire molecule was improved to a large extent as a result of the formation of cationic quaternary ammonium salt, while the strong fluorescence inherent to the BODIPY dye fragment is extinguished on alkylation of the pyridine N atom due to the photo- induced electron transfer (PET) process. The N-alkylated BODIPY derivative 4, as a novel water-soluble “Turn-On” fluorescent probe for the discrimination of H2O2, was constructed by incorporating 4-(Bromomethyl)benzeneboronic acid pinacol ester moiety, which showed highly selective fluorescent response to H2O2 against other interferences of ROS and RNS species under physiological conditions, and the reaction mechanism of boronate oxidation was confirmed by 1H NMR, mass spectrum and optical spectroscopy analysis. As a biocompatible probe in biological systems, probe 4 was successfully applied for monitoring and imaging of H2O2 both in vitro and in vivo using HepG2/LO2 cells and angelfish. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (20972170;21275150);the Funds for Distinguished Young Scientists of Gansu (1210RJDA013);the Natural Science Foundation of Gansu province (1107RJYA069) |
| 语种 | 英语 |
| WOS记录号 | WOS:000333781000010 |
| 公开日期 | 2015-01-07 |
| 源URL | [http://210.77.64.217/handle/362003/7099]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 通讯作者 | Shao SJ(邵士俊) |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu J,Li Q,Yue Y,et al. A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo[J]. Biosensors and Bioelectronics,2014,56:58-63. |
| APA | Xu J,Li Q,Yue Y,Guo Y,Shao SJ,&邵士俊.(2014).A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo.Biosensors and Bioelectronics,56,58-63. |
| MLA | Xu J,et al."A water-soluble BODIPY derivative as a highly selective "Turn-On" fluorescent sensor for H2O2 sensing in vivo".Biosensors and Bioelectronics 56(2014):58-63. |
入库方式： OAI收割
来源：兰州化学物理研究所
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