Green Fabrication of Porous Chitosan/Graphene Oxide Composite Xerogels for Drug Delivery
文献类型：期刊论文
| 作者 | Chen YP(陈云平)1,2; Qi YY(齐园园)1,3; Yan XB(阎兴斌)1,3 ; Ma HB(马海滨)1,4; Chen JT(陈江涛)1,3; Liu B(刘斌)2; Xue QJ(薛群基)3; Yan XB(阎兴斌); Yan XB(阎兴斌)
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| 刊名 | Journal of Applied Polymer Science
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| 出版日期 | 2014 |
| 卷号 | 131期号:6页码:40006(1-11) |
| 关键词 | adsorption biomaterials biomedical applications drug-delivery systems |
| ISSN号 | 0021-8995 |
| 通讯作者 | 阎兴斌 ; 刘斌 |
| 英文摘要 | Porous chitosan (CS)/graphene oxide (GO) composite xerogels were prepared through a simple and “green” freeze-drying method. Scanning electron microscopy, Fourier transform infrared spectrometry, powder X-ray diffraction, and compressive strength measurements were performed to characterize the microstructures and mechanical properties of as-prepared composite xerogels. The results show that the incorporation of GO resulted in an observable change in the porous structure and an obvious increase in the compressive strength. The abilities of the composite xerogels to absorb and slowly release an anticancer drug, doxorubicin hydrochloride (DOX), in particular, the influence of different GO contents, were investigated systematically. The porous CS/GO composite xerogels exhibited efficient DOX-delivery ability, and both the adsorption and slow-release abilities increased obviously with increasing GO content. Additionally, the best adsorption concentration of DOX was 0.2 mg/mL, and the cumulative release percentage of DOX from the xerogels at pH4 much higher than that at pH 7.4. Therefore, such porous CS/GO composite xerogels could be promising materials as postoperation implanting stents for the design of new anticancer drug-release carriers. |
| 学科主题 | 材料科学与物理化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (contract grant number 51005225);the Top Hundred Talents Program of the Chinese Academy of Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000331004800064 |
| 公开日期 | 2015-02-05 |
| 源URL | [http://210.77.64.217/handle/362003/7141]  |
| 专题 | 兰州化学物理研究所_清洁能源化学与材料实验室 兰州化学物理研究所_固体润滑国家重点实验室 |
| 通讯作者 | Yan XB(阎兴斌); Yan XB(阎兴斌) |
| 作者单位 | 1.Lanzhou Univ, Lanzhou Inst Chem Phys, Lab Clean Energy Chem & Mat, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 4.Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen YP,Qi YY,Yan XB,et al. Green Fabrication of Porous Chitosan/Graphene Oxide Composite Xerogels for Drug Delivery[J]. Journal of Applied Polymer Science,2014,131(6):40006(1-11). |
| APA | Chen YP.,Qi YY.,Yan XB.,Ma HB.,Chen JT.,...&阎兴斌.(2014).Green Fabrication of Porous Chitosan/Graphene Oxide Composite Xerogels for Drug Delivery.Journal of Applied Polymer Science,131(6),40006(1-11). |
| MLA | Chen YP,et al."Green Fabrication of Porous Chitosan/Graphene Oxide Composite Xerogels for Drug Delivery".Journal of Applied Polymer Science 131.6(2014):40006(1-11). |
入库方式： OAI收割
来源：兰州化学物理研究所
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