Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus
文献类型：期刊论文
| 作者 | [Huang, Xiaohong ; Huang, Youhua ; Cai, Jia ; Wei, Shina ; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China |
| 刊名 | VIRUS RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 178期号:2页码:340-348 |
| 关键词 | SGIV Ranavirus VP96 TNFR Apoptosis Cell proliferation |
| ISSN号 | 0168-1702 |
| 其他题名 | mannual of IR |
| 产权排序 | 产权排序 |
| 通讯作者 | qinqw@scsio.ac.cn |
| 合作状况 | 填入合作性质等 |
| 中文摘要 | Virus encoded tumor necrosis factor receptors (TNFRs) have been demonstrated to facilitate virus to escape from apoptosis or other host immune response for viral replication. Singapore grouper iridovirus (SGIV), a large DNA virus which belongs to genus Ranavirus, is a major pathogen resulting in heavy economic losses to grouper aquaculture. Here, SGIV ORF096 (VP96) encoding a putative homolog of TNFR was identified and characterized. Multiple sequence alignment indicated that SGIV-VP96 contained two extracellular cysteine-rich domains (CRDs) with conserved four or six cysteine residues, but lacked the transmembrane domain at the C-terminus. SGIV-VP96 was identified as an early (E) gene and localized in the cytoplasm in transfected or infected cells. Overexpression of SGIV-VP96 in vitro enhanced cell proliferation, and improved cell survival against SGIV infection. Furthermore, virus infection induced apoptosis and caspase-3 activity were inhibited in SGIV-VP96 expressing FHM cells compared to the control cells. Taken together, our results suggested that SGIV might utilize virus encoded TNFR like genes to modulate the host apoptotic response for effective virus replication. (C) 2013 Elsevier B.V. All rights reserved. |
| 英文摘要 | description.abstract |
| 学科主题 | Virology |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). |
| 原文出处 | ELSEVIER SCIENCE BV |
| 语种 | 英语 |
| WOS记录号 | WOS:000329266300018 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10943]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Huang, Xiaohong,Huang, Youhua,Cai, Jia,et al. Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus[J]. VIRUS RESEARCH,2013,178(2):340-348. |
| APA | [Huang, Xiaohong,Huang, Youhua,Cai, Jia,Wei, Shina,Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China,&[Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China.(2013).Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus.VIRUS RESEARCH,178(2),340-348. |
| MLA | [Huang, Xiaohong,et al."Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus".VIRUS RESEARCH 178.2(2013):340-348. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。