Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification
文献类型：期刊论文
| 作者 | [Fan, Wenhong ; Li, Qian ; Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China ; [Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:11页码:-e78123 |
| ISSN号 | 1932-6203 |
| 通讯作者 | fanwh@buaa.edu.cn |
| 中文摘要 | Zinc Oxide Nanoparticles (ZnO NPs) have attracted increasing concerns because of their widespread use and toxic potential. In this study, Zn accumulations in different tissues (gills, liver, muscle, and gut) of goldfish (Carassius auratus) after exposure to ZnO NPs were studied in comparison with bulk ZnO and Zn2+. And the technique of subcellular partitioning was firstly used on the liver of goldfish to study the hepatic accumulation of ZnO NPs. The results showed that at sublethal Zn concentration (2 mg/L), bioaccumulation in goldfish was tissue-specific and dependent on the exposure materials. Compared with Zn2+, the particles of bulk ZnO and the ZnO NPs appeared to aggregate in the environmentally contacted tissues (gills and gut), rather than transport to the internal tissues (liver and muscle). The subcellular distributions of liver differed for the three exposure treatments. After ZnO NPs exposure, Zn percentage in metal-rich granule (MRG) increased significantly, and after Zn2+ exposure, it increased significantly in the organelles. Metallothionein-like proteins (MTLP) were the main target for Zn2+, while MRG played dominant role for ZnO NPs. The different results of subcellular distributions revealed that metal detoxification mechanisms of liver for ZnO NPs, bulk ZnO, and Zn2+ were different. Overall, subcellular partitioning provided an interesting start to better understanding of the toxicity of nano-and conventional materials. |
| 学科主题 | Multidisciplinary Sciences |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (51290283), Major Science and Technology Program for Water Pollution Control and Treatment of China (No. 2012ZX07501001), and China's National Basic Research Program (No. 2011CB935700). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| 原文出处 | PUBLIC LIBRARY SCIENCE |
| 语种 | 英语 |
| WOS记录号 | WOS:000326499300024 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10970]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Fan, Wenhong,Li, Qian,Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China,et al. Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification[J]. PLOS ONE,2013,8(11):-e78123. |
| APA | [Fan, Wenhong,Li, Qian,Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China,&[Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China.(2013).Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification.PLOS ONE,8(11),-e78123. |
| MLA | [Fan, Wenhong,et al."Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification".PLOS ONE 8.11(2013):-e78123. |
入库方式： OAI收割
来源：南海海洋研究所
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