Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety
文献类型：期刊论文
| 作者 | [Zhang, Yun ; Huang, Hongbo ; Chen, Qi ; Luo, Minghe ; Sun, Aijun ; Song, Yongxiang ; Ma, Junying ; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:13页码:3254-3257 |
| ISSN号 | 1523-7060 |
| 通讯作者 | jju@scsio.ac.cn |
| 中文摘要 | The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The Delta gcnQ mutant accumulates intermediate la and two shunt products 2a and 3a bearing L-rhodinose for L-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two L-rhodinose moieties into L-aculose moieties, supporting divergent roles of GcnQ in different hosts. |
| 学科主题 | Chemistry, Organic |
| 资助信息 | This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). |
| 原文出处 | AMER CHEMICAL SOC |
| 语种 | 英语 |
| WOS记录号 | WOS:000321605800016 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11008]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Zhang, Yun,Huang, Hongbo,Chen, Qi,et al. Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety[J]. ORGANIC LETTERS,2013,15(13):3254-3257. |
| APA | [Zhang, Yun.,Huang, Hongbo.,Chen, Qi.,Luo, Minghe.,Sun, Aijun.,...&Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.(2013).Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety.ORGANIC LETTERS,15(13),3254-3257. |
| MLA | [Zhang, Yun,et al."Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety".ORGANIC LETTERS 15.13(2013):3254-3257. |
入库方式： OAI收割
来源：南海海洋研究所
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