Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius
文献类型：期刊论文
| 作者 | [Bringmann, Gerhard ; Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany ; [Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany ; [Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany ; [Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China ; [Chatterjee, Manik] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Dept Internal Med 2, D-97078 Wurzburg, Germany ; [Brun, Reto] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland ; [Brun, Reto] Univ Basel, CH-4003 Basel, Switzerland |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 91页码:220-228 |
| 关键词 | Ancistrocladus tectorius Ancistrocladaceae Naphthylisoquinoline alkaloids Structural elucidation Anti-parasitic activity |
| ISSN号 | 0031-9422 |
| 通讯作者 | bringman@chemie.uni-wuerzburg.de |
| 中文摘要 | Naphthylisoquinoline alkaloids, named ancistectorine A(1), N-methylancistectorine A(1), ancistectorine A(2), 5-epi-ancistectorine A(2), ancistectorine A(3), ancistectorine B-1, and ancistectorine C-1, have been isolated from twigs of the Chinese plant Ancistrocladus tectorius. The structural elucidation succeeded by chemical, spectroscopic, and chiroptical methods. Three of these compounds exhibited excellent, and specific, anti-plasmodial activities, comparable with that of the as yet most active representative, dioncophylline C. Moreover, the antitumoral activities of two of the main alkaloids in this species was tested. (C) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| 资助信息 | This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. |
| 原文出处 | PERGAMON-ELSEVIER SCIENCE LTD |
| 语种 | 英语 |
| WOS记录号 | WOS:000321727100023 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11010]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Bringmann, Gerhard,Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany,[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany,et al. Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius[J]. PHYTOCHEMISTRY,2013,91:220-228. |
| APA | [Bringmann, Gerhard.,Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.,[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany.,[Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany.,[Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.,...&[Brun, Reto] Univ Basel, CH-4003 Basel, Switzerland.(2013).Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius.PHYTOCHEMISTRY,91,220-228. |
| MLA | [Bringmann, Gerhard,et al."Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius".PHYTOCHEMISTRY 91(2013):220-228. |
入库方式： OAI收割
来源：南海海洋研究所
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