Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation
文献类型：期刊论文
| 作者 | [Wang, Bo ; Song, Yongxiang ; Luo, Minghe ; Chen, Qi ; Ma, Junying ; Huang, Hongbo ; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:6页码:1278-1281 |
| ISSN号 | 1523-7060 |
| 通讯作者 | jju@scsio.ac.cn |
| 中文摘要 | 9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene cluster responsible for the biosynthesis of 9-methylstreptimidone in Streptomyces himastatinicus. The unveiled machinery features both acyltransferase- and thioesterase-less iterative use of module 5 as well as a branching module for glutarimide generation. Impressively, inactivation of smdK leads to a new carboxylate analogue unveiling a new mechanism for polyketide terminal diene formation. |
| 学科主题 | Chemistry, Organic |
| 资助信息 | This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). |
| 原文出处 | AMER CHEMICAL SOC |
| 语种 | 英语 |
| WOS记录号 | WOS:000316520300032 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11051]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Wang, Bo,Song, Yongxiang,Luo, Minghe,et al. Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation[J]. ORGANIC LETTERS,2013,15(6):1278-1281. |
| APA | [Wang, Bo.,Song, Yongxiang.,Luo, Minghe.,Chen, Qi.,Ma, Junying.,...&Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.(2013).Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation.ORGANIC LETTERS,15(6),1278-1281. |
| MLA | [Wang, Bo,et al."Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation".ORGANIC LETTERS 15.6(2013):1278-1281. |
入库方式： OAI收割
来源：南海海洋研究所
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