Marine Natural Products with Anti-HIV Activities in the Last Decade
文献类型：期刊论文
| 作者 | [Zhou, Xuefeng ; Liu, Juan ; Yang, Bin ; Lin, Xiuping ; Yang, Xian-Wen ; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China |
| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 20期号:7页码:953-973 |
| 关键词 | Anti-HIV HIV entry inhibitors last decade marine organisms natural products sponges |
| ISSN号 | 0929-8673 |
| 通讯作者 | yonghongliu@scsio.ac.cn |
| 中文摘要 | Marine organisms have been proven to be excellent sources of biologically active compounds against HIV. This review gives an overview of 132 natural products from marine sources obtained during the last decade (2002-2011), which exhibit anti-HIV activity toward different biological targets. Sponges contribute more than half of all anti-HIV natural products from marine organisms, mainly as alkaloids and cyclic depsipeptides. In addition, some macromolecules are considered as potential anti-HIV agents, including lectins from algae and marine invertebrates, as well as sulfated polysaccharides from algae. In the reviewed marine natural products, many active ingredients act as HIV entry inhibitors, one class of new anti-HIV agents, and may be regarded as potential candidates for the development of novel anti-HIV agents. The other features of development in the marine original anti-HIV natural products in this ten years are also discussed. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). |
| 原文出处 | BENTHAM SCIENCE PUBL LTD |
| 语种 | 英语 |
| WOS记录号 | WOS:000316610600009 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11063]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Zhou, Xuefeng,Liu, Juan,Yang, Bin,et al. Marine Natural Products with Anti-HIV Activities in the Last Decade[J]. CURRENT MEDICINAL CHEMISTRY,2013,20(7):953-973. |
| APA | [Zhou, Xuefeng,Liu, Juan,Yang, Bin,Lin, Xiuping,Yang, Xian-Wen,&Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China.(2013).Marine Natural Products with Anti-HIV Activities in the Last Decade.CURRENT MEDICINAL CHEMISTRY,20(7),953-973. |
| MLA | [Zhou, Xuefeng,et al."Marine Natural Products with Anti-HIV Activities in the Last Decade".CURRENT MEDICINAL CHEMISTRY 20.7(2013):953-973. |
入库方式： OAI收割
来源：南海海洋研究所
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