Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome
文献类型：期刊论文
| 作者 | [Shi, Wei ; Kong, Xiao-Yu ; Wang, Zhong-Ming ; Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China ; [Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden ; [De Stasio, Elizabeth A.] Lawrence Univ, Dept Biol, Appleton, WI 54911 USA |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2013 |
| 卷号 | 14页码:-103 |
| ISSN号 | 1471-2164 |
| 通讯作者 | xykong@scsio.ac.cn |
| 中文摘要 | Background: Tandem repeats (TRs) in the mitochondrial (mt) genome control region have been documented in a wide variety of vertebrate species. The mechanism by which repeated tracts originate and undergo duplication and deletion, however, remains unclear. Results: We analyzed DNA sequences of mt genome TRs (mtTRs) in the ridged-eye flounder (Pleuronichthys cornutus), and characterized DNA sequences of mtTRs from other vertebrates using the data available in GenBank. Tandem repeats are concentrated in the control regions; however, we found approximately 16.6% of the TRs elsewhere in the mt genome. The flounder mtTRs possess three motif types with hypervariable characteristics at the 30 end of the control region (CR). Conclusion: Based on our analysis of this larger dataset of mtTR sequences, we propose a novel model of Pause Melting Misalignment (PMM) to describe the birth and motif indel of tandem repeats. PMM is activated during a pause event in mitochondrial replication in which a dynamic competition between the nascent (N) heavy strand and the displaced (D) heavy strand may lead to the melting of the N-strand from the template (T) light strand. When mispairing occurs during rebinding of the N-strand, one or several motifs can be inserted or deleted in both strands during the next round of mt-replication or repair. This model can explain the characteristics of TRs in available vertebrate mt genomes. |
| 学科主题 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 资助信息 | This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. |
| 原文出处 | BIOMED CENTRAL LTD |
| 语种 | 英语 |
| WOS记录号 | WOS:000316007600001 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11069]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Shi, Wei,Kong, Xiao-Yu,Wang, Zhong-Ming,et al. Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome[J]. BMC GENOMICS,2013,14:-103. |
| APA | [Shi, Wei,Kong, Xiao-Yu,Wang, Zhong-Ming,Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China,[Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden,&[De Stasio, Elizabeth A.] Lawrence Univ, Dept Biol, Appleton, WI 54911 USA.(2013).Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome.BMC GENOMICS,14,-103. |
| MLA | [Shi, Wei,et al."Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome".BMC GENOMICS 14(2013):-103. |
入库方式： OAI收割
来源：南海海洋研究所
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