Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.
文献类型：期刊论文
| 作者 | [Yang, Xian-Wen ; Steinmetz, Andre ; Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg ; [Yang, Xian-Wen ; Yang, Bing ; Zhou, Xue-Feng ; Liu, Yong-Hong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China ; [Zhang, Gai-Yun ; Ying, Jian-Xi] State Ocean Adm, Key Lab Marine Biogenet Resources, Inst Oceanog 3, Xiamen 361005, Peoples R China |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2013 |
| 卷号 | 11期号:1页码:33-39 |
| 关键词 | deep-sea sediment actinomycete Serinicoccus profundi sp nov. alkaloid antibacterial activity cytotoxicity |
| ISSN号 | 1660-3397 |
| 通讯作者 | xianwen.yang@crp-sante.lu ; zhgyun2008@yahoo.com.cn ; yingjianxiah@126.com ; bingo525@163.com ; xfzhou@scsio.ac.cn ; andre.steinmetz@crp-sante.lu ; yonghongliu@scsio.ac.cn ; ning.wang@crp-sante.lu |
| 中文摘要 | One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 mu g/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702). |
| 学科主题 | Chemistry, Medicinal |
| 资助信息 | This study was supported by grants from the FP7-People-IRSES-2008 (TCMCANCER Project 230232), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 20902094), Knowledge Innovation Program of Chinese Academy of Science (SQ200904, SQ201117), and the Ocean Public Welfare Scientific Research Project the State Oceanic Administration of China (201005022). |
| 原文出处 | MDPI AG |
| 语种 | 英语 |
| WOS记录号 | WOS:000314040300003 |
| 公开日期 | 2015-01-22 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/11082]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | [Yang, Xian-Wen,Steinmetz, Andre,Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg,et al. Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.[J]. MARINE DRUGS,2013,11(1):33-39. |
| APA | [Yang, Xian-Wen.,Steinmetz, Andre.,Wang, Ning] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg.,[Yang, Xian-Wen.,Yang, Bing.,...&Ying, Jian-Xi] State Ocean Adm, Key Lab Marine Biogenet Resources, Inst Oceanog 3, Xiamen 361005, Peoples R China.(2013).Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov..MARINE DRUGS,11(1),33-39. |
| MLA | [Yang, Xian-Wen,et al."Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp nov.".MARINE DRUGS 11.1(2013):33-39. |
入库方式： OAI收割
来源：南海海洋研究所
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