Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level
文献类型：期刊论文
| 作者 | Okogwu, Okechukwu Idumah1,2; Xie, Ping2; Zhao, Yanyan2; Fan, Huihui2 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 112期号:-页码:427-434 |
| 关键词 | Antioxidant Goldfish Hypoxia Microcystin-RR Myoglobin Neuroglobin |
| ISSN号 | 0045-6535 |
| 英文摘要 | Cyanobacterial bloom, a common phenomenon nowadays often results in the depletion of dissolved oxygen (hypoxia) and releases microcystin-RR (MC-RR) in the water. Information on the combined effects of MC-RR and hypoxia on the goldfish is lacking, therefore, this study is aimed at evaluating the effect of two doses of MC-RR on the antioxidants and globin mRNA of goldfish under normoxia, hypoxia and reoxygenation. The result showed that MC-RR at both doses (50 and 200 mu g kg(-1) body weight) significantly (p < 0.05) induced superoxide dismutase activities in the liver and kidney but catalase activities and total antioxidant capacity were low in these organs during hypoxia and reoxygenation compared to normoxia and control. Myoglobin and neuroglobin mRNAs in MC-RR group were significantly induced in the brain only and are believed to protect the brain from oxidative damage. However, other organs were unprotected and extensive damage was observed in the liver cells. Our results clearly demonstrated that MC-RR and hypoxia-reoxygenation transitions were synergistically harmful to the goldfish and could impair its adaptation to hypoxia, especially during reoxygenation. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | OXIDATIVE STRESS ; MICROCYSTIN-LR ; IN-VIVO ; HYPOXIA ; LIVER ; PROTEIN ; GENES ; TRANSCRIPTION ; HEPATOCYTES ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340688300056 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20306]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Ebonyi State Univ, Dept Appl Biol, Abakaliki, Ebonyi State, Nigeria 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosystems, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Okogwu, Okechukwu Idumah,Xie, Ping,Zhao, Yanyan,et al. Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level[J]. CHEMOSPHERE,2014,112(-):427-434. |
| APA | Okogwu, Okechukwu Idumah,Xie, Ping,Zhao, Yanyan,&Fan, Huihui.(2014).Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level.CHEMOSPHERE,112(-),427-434. |
| MLA | Okogwu, Okechukwu Idumah,et al."Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level".CHEMOSPHERE 112.-(2014):427-434. |
入库方式： OAI收割
来源：水生生物研究所
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