Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis
文献类型：期刊论文
| 作者 | Huang, Wenmin1,2; Li, Dunhai1; Liu, Yongding1 |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2014-09-01 |
| 卷号 | 26期号:9页码:1930-1935 |
| 关键词 | Microcystin-RR Tobacco BY-2 cells Apoptosis Reactive oxygen species Mitochondrial electron transport chain |
| ISSN号 | 1001-0742 |
| 英文摘要 | Microcystin-RR (MC-RR) has been suggested to induce apoptosis in tobacco BY-2 cells through mitochondrial dysfunction including the loss of mitochondrial membrane potential (Delta Psi(m)). To further elucidate the mechanisms involved in MC-RR induced apoptosis in tobacco BY-2 cells, we have investigated the role of mitochondrial electron transport chain (ETC) as a potential source for reactive oxygen species (ROS). Tobacco BY-2 cells after exposure to MC-RR (60 mg/L) displayed apoptotic changes in association with an increased production of ROS and loss of Delta Psi(m). All of these adverse effects were significantly attenuated by ETC inhibitors including Rotenone (2 mu mol/L, complex I inhibitor) and antimycin A (0.01 mu mol/L, complex III inhibitor), but not by thenoyltrifluoroacetone (5 mu mol/L, complex II inhibitor). These results suggest that mitochondrial ETC plays a key role in mediating MC-RR induced apoptosis in tobacco BY-2 cells through an increased mitochondrial production of ROS. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | SUSPENSION CELLS ; LR ; HEPATOCYTES ; GENERATION ; PATHWAY ; TOXIN ; ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341739600022 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20362]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Aquat Bot & Watershed Ecol, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Wenmin,Li, Dunhai,Liu, Yongding. Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2014,26(9):1930-1935. |
| APA | Huang, Wenmin,Li, Dunhai,&Liu, Yongding.(2014).Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,26(9),1930-1935. |
| MLA | Huang, Wenmin,et al."Mitochondrial electron transport chain is involved in microcystin-RR induced tobacco BY-2 cells apoptosis".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 26.9(2014):1930-1935. |
入库方式： OAI收割
来源：水生生物研究所
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