The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish
文献类型：期刊论文
| 作者 | Zhang, J.1,2; Cui, X.2; Wang, L.1; Liu, F.1; Jiang, T.1; Li, C.1; Li, D.1; Huang, M.1; Liao, S.1; Wang, J.1 |
| 刊名 | CURRENT MOLECULAR MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:6页码:772-782 |
| 关键词 | Apoptosis Bcl-2 family liver morphogenesis MPP Trx2 zebrafish |
| ISSN号 | 1566-5240 |
| 英文摘要 | Thioredoxins (Trxs) are a class of small molecular redox proteins that play an important role in scavenging abnormally accumulated reactive oxygen species (ROS). Thioredoxin 2 (Trx2) is one member of this family located in mitochondria. Trx2 protects cells from increased oxidative stress and has anti-apoptosis function. Knockout of Trx2 in mice led to early embryonic lethality. However, the essential role of Trx2 during embryogenesis remains unclear. To further investigate the role of Trx2 during embryonic development, we performed Trx2 knockdown in zebrafish and investigated the regulation role of Trx2 during embryonic development. Our results indicate that Trx2 had a high expression in early zebrafish embryos and its knockdown in zebrafish led to defective liver development mainly due to increased hepatic cell death. The increased ROS and the imbalance of members of the Bcl-2 family were involved in cell death induced by Trx2 suppression in zebrafish. The dysregulation of Bax, puma and Bcl-xl promoted the reduction of mitochondrial trans-membrane potential and the mitochondria membrane permeabilization (MMP), which initiated the mitochondrial apoptosis pathway. Additionally, we found that the increase of relocated GAPDH in mitochondria may be another factor responsible for the mitochondrial catastrophe. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | OUTER-MEMBRANE PERMEABILIZATION ; CELL-DEATH ; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ; OXIDATIVE STRESS ; APOPTOSIS ; BAX ; NUCLEAR ; PUMA ; EXPRESSION ; REDUCTASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341015600007 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20390]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Ctr Human Genome Res, Key Lab Mol Biophys,Minist Educ, Wuhan 430074, Hubei, Peoples R China 2.Henan Univ, Coll Med, Inst Immunol, Key Lab Cellular & Mol Immunol, Kaifeng, Henan, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, J.,Cui, X.,Wang, L.,et al. The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish[J]. CURRENT MOLECULAR MEDICINE,2014,14(6):772-782. |
| APA | Zhang, J..,Cui, X..,Wang, L..,Liu, F..,Jiang, T..,...&Liu, M..(2014).The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish.CURRENT MOLECULAR MEDICINE,14(6),772-782. |
| MLA | Zhang, J.,et al."The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish".CURRENT MOLECULAR MEDICINE 14.6(2014):772-782. |
入库方式： OAI收割
来源：水生生物研究所
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