Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus
文献类型：期刊论文
| 作者 | Zhu, Rong; Chen, Zhong-Yuan; Wang, Jun; Yuan, Jiang-Di; Liao, Xiang-Yong; Gui, Jian-Fang; Zhang, Qi-Ya |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 46期号:2页码:413-422 |
| ISSN号 | 0145-305X |
| 关键词 | Immune gene Immunoglobulin Chinese giant salamander Andrias davidianus Thymus cDNA library Ranavirus-induced |
| 英文摘要 | A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCR beta). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(Delta Fc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCR beta immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Zoology |
| 研究领域[WOS] | Immunology ; Zoology |
| 关键词[WOS] | IMMUNOGLOBULIN HEAVY-CHAIN ; EXTENSIVE DIVERSIFICATION ; XENOPUS-TROPICALIS ; AMPHIBIAN XENOPUS ; IGD ; IDENTIFICATION ; GENES ; EXPRESSION ; DISCOVERY ; LAEVIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340216600032 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20336]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Rong,Chen, Zhong-Yuan,Wang, Jun,et al. Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2014,46(2):413-422. |
| APA | Zhu, Rong.,Chen, Zhong-Yuan.,Wang, Jun.,Yuan, Jiang-Di.,Liao, Xiang-Yong.,...&Zhang, Qi-Ya.(2014).Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,46(2),413-422. |
| MLA | Zhu, Rong,et al."Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 46.2(2014):413-422. |
入库方式： OAI收割
来源：水生生物研究所
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