Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin
文献类型：期刊论文
| 作者 | Xie, Hai-Xia1,2; Lu, Jin-Fang1; Rolhion, Nathalie2; Holden, David W.2; Nie, Pin1; Zhou, Ying1; Yu, Xiu-Jun2 |
| 刊名 | INFECTION AND IMMUNITY
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 82期号:8页码:3436-3445 |
| ISSN号 | 0019-9567 |
| 关键词 | ENTERICA SEROVAR TYPHIMURIUM CELL-DEATH SALMONELLA-ENTERICA GENE-EXPRESSION IN-VIVO 2-COMPONENT SYSTEM NLRC4 INFLAMMASOME ESCHERICHIA-COLI PHOP-PHOQ HOST |
| 英文摘要 | Many Gram-negative bacteria utilize a type III secretion system (T3SS) to translocate virulence proteins into host cells to cause diseases. In responding to infection, macrophages detect some of the translocated proteins to activate caspase-1-mediated cell death, called pyroptosis, and secretion of proinflammatory cytokines to control the infection. Edwardsiella tarda is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish and both gastrointestinal and extraintestinal infections in humans. In this study, we report that the T3SS of E. tarda facilitates its survival and replication in murine bone marrow-derived macrophages, and E. tarda infection triggers pyroptosis of infected macrophages from mice and fish and increased secretion of the cytokine interleukin 1 beta in a T3SS-dependent manner. Deletion of the flagellin gene fliC of E. tarda results in decreased cytotoxicity for infected macrophages and does not attenuate its virulence in a fish model of infection, whereas upregulated expression of FliC in the fliC mutant strain reduces its virulence. We propose that the host controls E. tarda infection partially by detecting FliC translocated by the T3SS, whereas the bacteria downregulate the expression of FliC to evade innate immunity. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Infectious Diseases |
| 研究领域[WOS] | Immunology ; Infectious Diseases |
| 关键词[WOS] | ENTERICA SEROVAR TYPHIMURIUM ; CELL-DEATH ; SALMONELLA-ENTERICA ; GENE-EXPRESSION ; IN-VIVO ; 2-COMPONENT SYSTEM ; NLRC4 INFLAMMASOME ; ESCHERICHIA-COLI ; PHOP-PHOQ ; HOST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339161400032 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/20348]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China 2.Univ London Imperial Coll Sci Technol & Med, Ctr Mol Bacteriol & Infect, MRC, Microbiol Sect, London, England |
| 推荐引用方式 GB/T 7714 | Xie, Hai-Xia,Lu, Jin-Fang,Rolhion, Nathalie,et al. Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin[J]. INFECTION AND IMMUNITY,2014,82(8):3436-3445. |
| APA | Xie, Hai-Xia.,Lu, Jin-Fang.,Rolhion, Nathalie.,Holden, David W..,Nie, Pin.,...&Yu, Xiu-Jun.(2014).Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin.INFECTION AND IMMUNITY,82(8),3436-3445. |
| MLA | Xie, Hai-Xia,et al."Edwardsiella tarda-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin".INFECTION AND IMMUNITY 82.8(2014):3436-3445. |
入库方式： OAI收割
来源：水生生物研究所
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