Indole Alkaloids with New Skeleton Activating Neural Stem Cells
文献类型：期刊论文
| 作者 | Yang, Xing-Wei1,3 ; Yang, Cui-Ping2; Jiang, Li-Ping2,3; Qin, Xu-Jie1,3; Liu, Ya-Ping1; Shen, Qiu-Shuo2,3; Chen, Yong-Bin2; Luo, Xiao-Dong1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-11-07 |
| 卷号 | 16期号:21页码:5808-5811 |
| 关键词 | ENIGMATIC RELATIONSHIPS BAYESIAN PHYLOGENETICS EVOLUTIONARY HISTORY C-4 PHOTOSYNTHESIS PLASTID GENOMES GRASSES POACEAE TREE SELECTION WOODY BAMBOOS MIXED MODELS NUCLEAR LOCI Branch length chloroplast phylogenomics data partitioning low sequence divergence sampling temperate woody bamboos |
| ISSN号 | 1523-7060 |
| 产权排序 | 第一 |
| 通讯作者 | Chen,YB (reprint author),Chinese Acad Sci,Kunming Inst Zool,Key Lab Anim Models & Human Dis Mechanisms,Kunming 650223,Peoples R China. ; ybchen@mail.kiz.ac.cn ; xdluo@mail.kib.ac.cn |
| 英文摘要 | Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 rho g/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ALSTONIA-SCHOLARIS ; NEUROGENESIS ; PROLIFERATION |
| 收录类别 | SCI ; IC |
| 资助信息 | Royal Golden Jubilee Ph. D. Program under Thailand Research Fund [PHD/0090/2551]; Humidtropics, a CGIAR Research Program; Mae Fah Luang University [56101020032]; Chinese Academy of Sciences [2013T2S0030] |
| 语种 | 英语 |
| WOS记录号 | WOS:000344635200077 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18456]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xing-Wei,Yang, Cui-Ping,Jiang, Li-Ping,et al. Indole Alkaloids with New Skeleton Activating Neural Stem Cells[J]. ORGANIC LETTERS,2014,16(21):5808-5811. |
| APA | Yang, Xing-Wei.,Yang, Cui-Ping.,Jiang, Li-Ping.,Qin, Xu-Jie.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2014).Indole Alkaloids with New Skeleton Activating Neural Stem Cells.ORGANIC LETTERS,16(21),5808-5811. |
| MLA | Yang, Xing-Wei,et al."Indole Alkaloids with New Skeleton Activating Neural Stem Cells".ORGANIC LETTERS 16.21(2014):5808-5811. |
入库方式： OAI收割
来源：昆明植物研究所
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