Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica
文献类型：期刊论文
| 作者 | Lv, Jun-Jiang1,2; Wang, Ya-Feng3; Zhang, Jing-Min3,4; Yu, Shan1,2 ; Wang, Dong1; Zhu, Hong-Tao1; Cheng, Rong-Rong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 出版日期 | 2014 |
| 卷号 | 12期号:43页码:8764-8774 |
| 关键词 | CONSTITUENTS MODEL Aspongopus chinensis Insects Norepinephrine derivatives Sesquiterpenoids Lactam Biological evaluation |
| ISSN号 | 1477-0520 |
| 产权排序 | 第一 |
| 通讯作者 | Xu,M (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; minxu@mail.kib.ac.cn ; zhangyj@mail.kib.ac.cn |
| 英文摘要 | During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1-G8 (1-8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [3.1.1.1] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6-G8 (6-8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6-9 displayed potential anti-hepatitis B virus (HBV) activities, especially for the new compound 6 with IC50 of 8.53 +/- 0.97 and 5.68 +/- 1.75 mu M towards the HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | NATURAL-PRODUCTS ; ROOTS ; SECRETION ; NORSESQUITERPENOIDS ; NORBISABOLANE ; PYRIMIDINE |
| 收录类别 | SCI ; IC |
| 资助信息 | National Basic Research Program of China (973 Program) [2009CB522300]; National Natural Sciences Foundation of China [U113260, 81102346]; Hebei University |
| 语种 | 英语 |
| WOS记录号 | WOS:000343990200024 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18464]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China 4.Zhengzhou Univ, Acad Med & Pharmaceut Sci, Henan Key Lab Pharmacol Liver Dis, Zhengzhou 450052, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Jun-Jiang,Wang, Ya-Feng,Zhang, Jing-Min,et al. Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(43):8764-8774. |
| APA | Lv, Jun-Jiang.,Wang, Ya-Feng.,Zhang, Jing-Min.,Yu, Shan.,Wang, Dong.,...&Zhang, Ying-Jun.(2014).Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica.ORGANIC & BIOMOLECULAR CHEMISTRY,12(43),8764-8774. |
| MLA | Lv, Jun-Jiang,et al."Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica".ORGANIC & BIOMOLECULAR CHEMISTRY 12.43(2014):8764-8774. |
入库方式： OAI收割
来源：昆明植物研究所
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