Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A
文献类型：期刊论文
| 作者 | Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; Cheng, Yongxian2; Peng, Yuefeng1; Su, Wu1 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 67期号:34页码:7572-7576 |
| 关键词 | Synthetic methods Solid-phase synthesis Amidation Peptides Total synthesis |
| ISSN号 | 1434-193X |
| 产权排序 | 第三 |
| 通讯作者 | Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China. ; yuefeng.peng@fda.hhs.gov ; wu.su@siat.ac.cn |
| 英文摘要 | A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | AMIDE BOND FORMATION ; IN-SITU GENERATION ; DIABETIC-NEPHROPATHY ; CHEMICAL-SYNTHESIS ; PEPTIDE-SYNTHESIS ; ORGANIC-SYNTHESIS ; AMINO-ACIDS ; REAGENTS ; CALYCINUM ; INFLAMMATION |
| 收录类别 | SCI |
| 资助信息 | Independent Research Program of the Chinese Academy of Sciences [KSCX2-EW-J-24]; National Natural Science Foundation of China [31270273, 31070192, 30770167]; Basic Research Program from the Ministry of Science and Technology of China [2007FY110100] |
| 语种 | 英语 |
| WOS记录号 | WOS:000345506700007 |
| 公开日期 | 2015-01-20 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18474]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576. |
| APA | Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&Su, Wu.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576. |
| MLA | Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576. |
入库方式： OAI收割
来源：昆明植物研究所
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