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Coordinating Expression of RNA Binding Proteins with Their mRNA Targets

文献类型：期刊论文

作者Jiang, Huifeng1,2; Xu, Lin2; Wang, Zhe2; Keene, Jack3; Gu, Zhenglong2
刊名SCIENTIFIC REPORTS
出版日期2014-11-24
卷号4期号:7175
英文摘要Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their target mRNAs in yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend to dampen expression variation among their target mRNAs. We further examined a well-studied RBP gene, PUF3, and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay. We also constructed a mathematical model to explain the relationship between RBPs and the expression of their target genes. Our results provided new insights into the functional importance of RBPs in coordinating the expression of their target genes.
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENE-EXPRESSION ; REGULATORY NETWORK ; GENOME-WIDE ; YEAST ; MICRORNAS ; REGULONS ; NOISE ; TRANSCRIPTOME ; CANALIZATION ; BIOGENESIS
收录类别SCI
语种英语
WOS记录号WOS:000346184200004
公开日期2015-01-24
源URL[http://124.16.173.210/handle/311007/703]  
专题天津工业生物技术研究所_酵母基因组工程课题组 江会锋_期刊论文
作者单位1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China
2.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27701 USA
推荐引用方式
GB/T 7714		 Jiang, Huifeng,Xu, Lin,Wang, Zhe,et al. Coordinating Expression of RNA Binding Proteins with Their mRNA Targets[J]. SCIENTIFIC REPORTS,2014,4(7175).
APA Jiang, Huifeng,Xu, Lin,Wang, Zhe,Keene, Jack,&Gu, Zhenglong.(2014).Coordinating Expression of RNA Binding Proteins with Their mRNA Targets.SCIENTIFIC REPORTS,4(7175).
MLA Jiang, Huifeng,et al."Coordinating Expression of RNA Binding Proteins with Their mRNA Targets".SCIENTIFIC REPORTS 4.7175(2014).

入库方式： OAI收割

来源：天津工业生物技术研究所

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