The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model
文献类型：期刊论文
| 作者 | Silva, C. R. |
| 刊名 | Journal of Ethnopharmacology
 |
| 出版日期 | 2013 |
| 卷号 | 145期号:1页码:205-213 |
| ISSN号 | 0378-8741 |
| 中文摘要 | Ethnopharmacological relevance: Jatropha isabellei Mull Arg. (Euphorbiaceae) is a medicinal plant that has been used in South American folk medicine for the treatment of arthritic diseases, particularly gout. Aim of the study: This study was designed to verify the antinociceptive, anti-inflammatory and hypouricemic potential of Jarropha isabellei. Materials and methods: Rats were orally administered with the crude extract (100-300 mg/kg) or a fraction that is rich in alkaloids (0.15 mg/kg) of Jatropha isabellei. An intra-articular (i.a.) injection of 50 mu l of monosodium urate (MSU) crystals (1.25 mg/site) was used to generate the gout model to assess the effect of the treatment on nociception (thermal and mechanical hyperalgesia) and inflammation (oedema and neutrophil infiltration). The effect of Jatropha isabellei on the serum levels of uric acid was evaluated in a model of hyperuricaemia induced by the intraperitoneal injection of potassium oxonate (250 mg/kg). The side effects were analysed using an open-field test, gastric lesion assessment and by measuring the levels of the ALT and AST enzymes. Results: Our study demonstrated that the crude extract of Jatropha isabellei and a fraction rich in alkaloids were able to prevent the thermal hyperalgesia, mechanical allodynia, oedema and neutrophil infiltration induced by intra-articular MSU injection in rats. On the other hand, treatment with Jatropha isabellei did not alter the uric acid levels increased by potassium oxonate in the hyperuricaemia model. In addition, Jatropha isabellei did not induce gastric lesions or liver damage and did not alter spontaneous locomotor activity. Conclusion: The crude extract of Jatropha isabellei and its fraction rich in alkaloid presents antinociceptive and anti-inflammatory effects in a rat gout model, similar to that observed after treatment with colchicine, supporting the traditional use of this plant in gouty patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 公开日期 | 2015-01-28 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/7432]  |
| 专题 | 西双版纳热带植物园_热带植物资源可持续利用重点实验室特色文献_小桐子相关文献 |
| 推荐引用方式 GB/T 7714 | Silva, C. R.. The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model[J]. Journal of Ethnopharmacology,2013,145(1):205-213. |
| APA | Silva, C. R..(2013).The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.Journal of Ethnopharmacology,145(1),205-213. |
| MLA | Silva, C. R.."The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model".Journal of Ethnopharmacology 145.1(2013):205-213. |
入库方式： OAI收割
来源：西双版纳热带植物园
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