A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects
文献类型：期刊论文
| 作者 | Gonzales, G. F. |
| 刊名 | Food and Chemical Toxicology
 |
| 出版日期 | 2014 |
| 卷号 | 65页码:168-176 |
| ISSN号 | 0278-6915 |
| 中文摘要 | The study was designed to assess acceptability and side-effects of consumption of sacha inchi oil, rich in alpha-linolenic acid and sunflower oil, rich in linoleic acid, in adult human subjects. Thirty subjects received 10 or 15 ml daily of sacha inchi or sunflower oil for 4 months. Acceptability was assessed with daily self-report and with a Likert test at the end of the study. Safety was assessed with self- recording of side-effects and with hepatic and renal markers. Primary efficacy variables were the change in lipid profile. Subjects reported low acceptability of sacha inchi oil at week-1 (37.5%). However, since week-6, acceptability was significantly increased to 81.25-93.75%. No differences were observed in acceptability with respect to sex or oil volume (P > 0.05). Most frequent adverse effects during first weeks of consuming sacha inchi oil or sunflower oil were nauseas. The side-effects were reduced with time. Biochemical markers of hepatic and kidney function were maintained unchanged. Serum total cholesterol and LDL cholesterol levels and arterial blood pressure were lowered with both oils (P < 0.05). Higher HDL-cholesterol was observed with sacha inchi oil at month-4. In conclusion, sacha inchi oil consumed has good acceptability after week-1 of consumption and it is safety. (C) 2014 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 公开日期 | 2015-02-11 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/8311]  |
| 专题 | 西双版纳热带植物园_热带植物资源可持续利用重点实验室特色文献_星油藤相关文献 |
| 推荐引用方式 GB/T 7714 | Gonzales, G. F.. A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects[J]. Food and Chemical Toxicology,2014,65:168-176. |
| APA | Gonzales, G. F..(2014).A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects.Food and Chemical Toxicology,65,168-176. |
| MLA | Gonzales, G. F.."A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects".Food and Chemical Toxicology 65(2014):168-176. |
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来源：西双版纳热带植物园
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