中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease

文献类型:期刊论文

作者Li, Meng ; Howson, Suzanne E. ; Dong, Kai ; Gao,Nan ; Ren,Jinsong ; Scott,Peter ; Qu,Xiaogang
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2014
卷号136期号:33页码:11655-11663
关键词CALCIUM-CHANNELS IN-VIVO PEPTIDE AGGREGATION INHIBITION TOXICITY BINDING COPPER OLIGOMERS METAL
ISSN号0002-7863
通讯作者Qu,XG
中文摘要Stereochemistry is a very important issue for the pharmaceutical industry and can determine drug efficacy. The design and synthesis of small molecules, especially chiral molecules, which selectively target and inhibit amyloid-beta (A beta) aggregation, represent valid therapeutic strategies for treatment of Alzheimer's disease (AD). Herein we report that two triple-helical dinuclear metallosupramolecular complexes can act as a novel class of chiral amyloid-beta inhibitors. Through targeting alpha/beta-discordant stretches at the early steps of aggregation, these metal complexes can enantioselectively inhibit A beta aggregation, which is demonstrated using fluorescent living cell-based screening and multiple biophysical and biochemical approaches. To the best of our knowledge, this is the first report of enantioselective inhibition of A beta aggregation. Intriguingly, as a promising candidate for AD
收录类别SCI收录期刊论文
语种英语
公开日期2015-03-16
源URL[http://ir.ciac.jl.cn/handle/322003/50632]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Li, Meng,Howson, Suzanne E.,Dong, Kai,et al. Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(33):11655-11663.
APA Li, Meng.,Howson, Suzanne E..,Dong, Kai.,Gao,Nan.,Ren,Jinsong.,...&Qu,Xiaogang.(2014).Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(33),11655-11663.
MLA Li, Meng,et al."Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.33(2014):11655-11663.

入库方式: OAI收割

来源:长春应用化学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。