Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease
文献类型:期刊论文
作者 | Li, Meng ; Howson, Suzanne E. ; Dong, Kai ; Gao,Nan ; Ren,Jinsong ; Scott,Peter ; Qu,Xiaogang |
刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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出版日期 | 2014 |
卷号 | 136期号:33页码:11655-11663 |
关键词 | CALCIUM-CHANNELS IN-VIVO PEPTIDE AGGREGATION INHIBITION TOXICITY BINDING COPPER OLIGOMERS METAL |
ISSN号 | 0002-7863 |
通讯作者 | Qu,XG |
中文摘要 | Stereochemistry is a very important issue for the pharmaceutical industry and can determine drug efficacy. The design and synthesis of small molecules, especially chiral molecules, which selectively target and inhibit amyloid-beta (A beta) aggregation, represent valid therapeutic strategies for treatment of Alzheimer's disease (AD). Herein we report that two triple-helical dinuclear metallosupramolecular complexes can act as a novel class of chiral amyloid-beta inhibitors. Through targeting alpha/beta-discordant stretches at the early steps of aggregation, these metal complexes can enantioselectively inhibit A beta aggregation, which is demonstrated using fluorescent living cell-based screening and multiple biophysical and biochemical approaches. To the best of our knowledge, this is the first report of enantioselective inhibition of A beta aggregation. Intriguingly, as a promising candidate for AD |
收录类别 | SCI收录期刊论文 |
语种 | 英语 |
公开日期 | 2015-03-16 |
源URL | [http://ir.ciac.jl.cn/handle/322003/50632] ![]() |
专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
推荐引用方式 GB/T 7714 | Li, Meng,Howson, Suzanne E.,Dong, Kai,et al. Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(33):11655-11663. |
APA | Li, Meng.,Howson, Suzanne E..,Dong, Kai.,Gao,Nan.,Ren,Jinsong.,...&Qu,Xiaogang.(2014).Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(33),11655-11663. |
MLA | Li, Meng,et al."Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer's Disease".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.33(2014):11655-11663. |
入库方式: OAI收割
来源:长春应用化学研究所
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