Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease
文献类型：期刊论文
| 作者 | Gao, Nan ; Sun, Hanjun ; Dong, Kai ; Ren,Jinsong ; Duan,Taicheng ; Xu,Can ; Qu,Xiaogang |
| 刊名 | nature communications
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:3422 |
| 关键词 | BETA-PEPTIDE PROTEASE INHIBITION A-BETA NANOPARTICLES AGGREGATION COPPER BINDING SYSTEM |
| ISSN号 | 2041-1723 |
| 通讯作者 | qu,xg |
| 中文摘要 | inhibitions of amyloid beta (a beta) aggregation and a beta-haem peroxidase-like activity have received much attention because these two symptoms can be the primary targets of therapeutic strategies for alzheimer's disease (ad). recently, our group found that polyoxometalate (pom) with a wells-dawson structure can efficiently inhibit a beta aggregation. however, the interaction between poms and a beta is robust, but still needs to improve a beta binding affinity. more importantly, it is unclear whether poms can cross the blood-brain barrier and decrease a beta-haem peroxidase-like activity. here we show that our designed series of transition metal-functionalized pom derivatives with a defined histidine-chelated binding site have much better a beta inhibition and peroxidase-like activity inhibition effects than the parent pom. more intriguingly, we show that these compounds can cross the blood-brain barrier and are metabolized after 48 h. our work provides insights into the design, synthesis and screening of inorganic metal compounds as multifunctional therapeutic agents against ad. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000334300400005 |
| 公开日期 | 2015-03-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50643]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Gao, Nan,Sun, Hanjun,Dong, Kai,et al. Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease[J]. nature communications,2014,5(3422). |
| APA | Gao, Nan.,Sun, Hanjun.,Dong, Kai.,Ren,Jinsong.,Duan,Taicheng.,...&Qu,Xiaogang.(2014).Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease.nature communications,5(3422). |
| MLA | Gao, Nan,et al."Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease".nature communications 5.3422(2014). |
入库方式： OAI收割
来源：长春应用化学研究所
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