Near-Infrared Light-Encoded Orthogonally Triggered and Logical Intracellular Release Using Gold Nanocage@Smart Polymer Shell
文献类型：期刊论文
| 作者 | Shi, Peng ; Ju, Enguo ; Ren, Jinsong ; Qu,Xiaogang |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:6页码:826-834 |
| 关键词 | MESOPOROUS SILICA DRUG-DELIVERY MOLECULAR COMPUTATION GENE-EXPRESSION NANOPARTICLES SYSTEM HYDROGELS PHOSPHATASE ABSORPTION DESIGN |
| ISSN号 | 1616-301x |
| 通讯作者 | shi,p |
| 中文摘要 | gold nanocages (auncs) with hollow interiors, porous walls, and tunable localized surface plasmon resonance (lspr) peaks in the nir region represent a promising platform for therapeutic applications, and can be used for orthogonally triggered release by choosing the right laser according to the aunc's lspr. auncs are prepared with different lsprs and covered with a smart polymer shell. laser irradiation in resonance with the lspr can trigger the release of a pre-loaded effector. as a proof of concept, enzyme and substrate (prodrug) are selectively released from two different auncs. enzymatic reactions only occur after successful opening of both types of aunc capsules. the system acts as an and logic gate. furthermore, if the aunc is loaded with isoenzyme or enzyme inhibitor, an or or inhibit logic gate operation is achieved. to the best of our knowledge, no reports have combined nir light-encoded orthogonally triggered release with prodrug activation processes to realize defined different logic operations for regulating the dosage of active drug in a specific region. the design is simple and spatial/temporal to control, and provides new insights into developing nir light-encoded, logically controlled, intracellular release systems. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000331953600014 |
| 公开日期 | 2015-03-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50646]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi, Peng,Ju, Enguo,Ren, Jinsong,et al. Near-Infrared Light-Encoded Orthogonally Triggered and Logical Intracellular Release Using Gold Nanocage@Smart Polymer Shell[J]. advanced functional materials,2014,24(6):826-834. |
| APA | Shi, Peng,Ju, Enguo,Ren, Jinsong,&Qu,Xiaogang.(2014).Near-Infrared Light-Encoded Orthogonally Triggered and Logical Intracellular Release Using Gold Nanocage@Smart Polymer Shell.advanced functional materials,24(6),826-834. |
| MLA | Shi, Peng,et al."Near-Infrared Light-Encoded Orthogonally Triggered and Logical Intracellular Release Using Gold Nanocage@Smart Polymer Shell".advanced functional materials 24.6(2014):826-834. |
入库方式： OAI收割
来源：长春应用化学研究所
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