Engineered CpG- Antigen Conjugates Protected Gold Nanoclusters as Smart Self- Vaccines for Enhanced Immune Response and Cell Imaging
文献类型：期刊论文
| 作者 | Tao, Yu ; Ju, Enguo ; Li, Zhenhua ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:7页码:1004-1010 |
| ISSN号 | 1616-301x |
| 关键词 | IN-VIVO IMMUNOSTIMULATORY OLIGONUCLEOTIDES NANOPARTICLE VACCINES SYNTHETIC VACCINES DIRECTED SYNTHESIS ESCHERICHIA-COLI DELIVERY FLUORESCENT ADJUVANT DESIGN |
| 通讯作者 | tao,y |
| 中文摘要 | a facile one-pot synthesis of fluorescent auncs by using ovalbumin-cpg oligodeoxynucleotides (odns) conjugates as the templates, which can elicit specific immunological responses, is demonstrated. through dual-delivery of protein antigen and cpg odns, the as-prepared auncs can act as smart self-vaccines to assist in generation of high immunostimulatory activity while simultaneously act as an imaging agent. the auncs-based vaccines are not thought to have not been reported so far, making this platform the first example of the usage of auncs as effective vaccines. furthermore, compared with the antigen, the immunostimulatory activity of the as-prepared auncs can not only be retained, but also can be effectively enhanced. these findings suggest the auncs-based vaccines may be utilized as safe and efficient immunostimulatory agents that are able to prevent and/or treat a variety of ailments. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000331962000014 |
| 公开日期 | 2015-03-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50647]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tao, Yu,Ju, Enguo,Li, Zhenhua,et al. Engineered CpG- Antigen Conjugates Protected Gold Nanoclusters as Smart Self- Vaccines for Enhanced Immune Response and Cell Imaging[J]. advanced functional materials,2014,24(7):1004-1010. |
| APA | Tao, Yu,Ju, Enguo,Li, Zhenhua,Ren,Jinsong,&Qu,Xiaogang.(2014).Engineered CpG- Antigen Conjugates Protected Gold Nanoclusters as Smart Self- Vaccines for Enhanced Immune Response and Cell Imaging.advanced functional materials,24(7),1004-1010. |
| MLA | Tao, Yu,et al."Engineered CpG- Antigen Conjugates Protected Gold Nanoclusters as Smart Self- Vaccines for Enhanced Immune Response and Cell Imaging".advanced functional materials 24.7(2014):1004-1010. |
入库方式： OAI收割
来源：长春应用化学研究所
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