A Smart Nanoassembly for Multistage Targeted Drug Delivery and Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Li, Zhenhua ; Dong, Kai ; Huang, Sa ; Ju,Enguo ; Liu,Zhen ; Yin,Meili ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:23页码:3612-3620 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES PHOTOTHERMAL THERAPY GENE DELIVERY IN-VIVO LIPOSOMES POLYMER PH CONJUGATE PEPTIDES CHIMERAS |
| ISSN号 | 1616-301x |
| 通讯作者 | li,zh |
| 中文摘要 | efficient delivery of dna-toxin anticancer drugs into nucleus of targeted tumor cells while simultaneously minimizing the side effects to normal tissue is a major challenge for cancer therapy. herein, a multistage continuous targeting strategy based on magnetic mesoporous silica nanoparticles to overcome the challenge is demonstrated. at the initial-stage, the magnetic nanoparticle is capable of efficiently accumulating in tumor tissue guided by magnet. following by the magnetic targeting, the targeting ligand gets it right into the cancer cell by receptor-mediated endocytosis. accompanied by endocytosis into the lysosomes, the nanoparticle reverses its surface charge from negative to positive which leads to the separation of charge-conversional polymer from the nanoparticle to re-expose the nuclear-targeting tat peptide. finally, tat peptide facilitates the carriers to enter nucleus and the dna-toxin camptothecin can inhibit topoisomerase i to induce cell apoptosis. furthermore, the nano-drug delivery system can be simultaneously used as predominant contrast agents for magnetic resonance imaging. this proof of concept might open the door to a new generation of carrier materials in the fields of targeted drug transport platform for cancer theranostics. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000337484300017 |
| 公开日期 | 2015-03-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50651]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, Zhenhua,Dong, Kai,Huang, Sa,et al. A Smart Nanoassembly for Multistage Targeted Drug Delivery and Magnetic Resonance Imaging[J]. advanced functional materials,2014,24(23):3612-3620. |
| APA | Li, Zhenhua.,Dong, Kai.,Huang, Sa.,Ju,Enguo.,Liu,Zhen.,...&Qu,Xiaogang.(2014).A Smart Nanoassembly for Multistage Targeted Drug Delivery and Magnetic Resonance Imaging.advanced functional materials,24(23),3612-3620. |
| MLA | Li, Zhenhua,et al."A Smart Nanoassembly for Multistage Targeted Drug Delivery and Magnetic Resonance Imaging".advanced functional materials 24.23(2014):3612-3620. |
入库方式： OAI收割
来源：长春应用化学研究所
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