G-Quadruplex binding enantiomers show chiral selective interactions with human telomere
文献类型：期刊论文
| 作者 | Wang, Jiasi ; Chen, Yong ; Ren, Jinsong ; Zhao,Chuanqi ; Qu,Xiaogang |
| 刊名 | nucleic acids research
 |
| 出版日期 | 2014 |
| 卷号 | 42期号:6页码:3792-3802 |
| 关键词 | END-PROTECTION PROBLEM DNA-DAMAGE RESPONSE REVERSE-TRANSCRIPTASE LIGAND RHPS4 CANCER-CELLS IN-VITRO NUCLEAR TRANSLOCATION ANTITUMOR-ACTIVITY LEUKEMIA-CELLS INHIBITION |
| ISSN号 | 0305-1048 |
| 通讯作者 | qu,xg |
| 中文摘要 | chiral recognition of dna molecules is important because dna chiral transition and its different conformations are involved in a series of important life events. among them, polymorphic human telomere dna has attracted great interests in recent years because of its important roles in chromosome structural integrity. in this report, we examine the short-term effect of chiral metallo-supramolecular complex enantiomers treatment on tumor cells, and find that a zinc-finger-like alpha helical chiral metallo-supramolecular complex, [ni2l3](4+)-p enantiomer (nip), can selectively provoke the rapid telomere uncapping, trigger dna damage responses at telomere and degradation of g-overhang and the delocalization of telomeric protein from telomeres. further studies indicate that nip can induce an acute cellular apoptosis and senescence in cancer cells rather than normal cells. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000334758600034 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50661]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang, Jiasi,Chen, Yong,Ren, Jinsong,et al. G-Quadruplex binding enantiomers show chiral selective interactions with human telomere[J]. nucleic acids research,2014,42(6):3792-3802. |
| APA | Wang, Jiasi,Chen, Yong,Ren, Jinsong,Zhao,Chuanqi,&Qu,Xiaogang.(2014).G-Quadruplex binding enantiomers show chiral selective interactions with human telomere.nucleic acids research,42(6),3792-3802. |
| MLA | Wang, Jiasi,et al."G-Quadruplex binding enantiomers show chiral selective interactions with human telomere".nucleic acids research 42.6(2014):3792-3802. |
入库方式： OAI收割
来源：长春应用化学研究所
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