Opposing enantiomers of tartaric acid anchored on a surface generate different insulin assemblies and hence contrasting cellular responses
文献类型：期刊论文
| 作者 | Wei, Weili ; Xu, Can ; Gao, Nan ; Ren,JS ; Qu,Xiaogang |
| 刊名 | chemical science
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:11页码:4367-4374 |
| 关键词 | AMYLOID FIBRIL FORMATION NERVE GROWTH-FACTOR PROTEIN ADSORPTION DESIGNING MATERIALS ADHESION BEHAVIOR MASS-SPECTROMETRY NEURITE FORMATION FACTOR-II CELLS PROLIFERATION |
| ISSN号 | 2041-6520 |
| 通讯作者 | qu,xg |
| 中文摘要 | chirality plays a pivotal role in biomolecule recognition, which is one of the key aspects of cell responses to a biomaterial surface. generally, the effects of the properties of a biomaterial surface on cellular responses are modulated by adsorbed proteins. surface chemistry, such as charge and hydrophobicity, has a profound effect on protein adsorption. nevertheless, chirality has been seldom considered in biomaterial surface chemistry. herein, using the classical biogenic chiral molecules, d-and l-tartaric acid, assembled into monolayers as a model chiral surface, we reported for the first time that surface chirality modulated insulin assembly, including the dynamics of adsorption, kinetics of the conformational transition and fibril formation, on d-and l-surfaces and determined the cellular effect of insulin on neuronal pc12 cells. on the d-surface, insulin retained its bioactivity; however, on the l-surface, insulin formed amyloid fibrils with lost bioactivity. previous reports have demonstrated that insulin can act as growth and neuronal differentiation factors. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000343004300032 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50665]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wei, Weili,Xu, Can,Gao, Nan,et al. Opposing enantiomers of tartaric acid anchored on a surface generate different insulin assemblies and hence contrasting cellular responses[J]. chemical science,2014,5(11):4367-4374. |
| APA | Wei, Weili,Xu, Can,Gao, Nan,Ren,JS,&Qu,Xiaogang.(2014).Opposing enantiomers of tartaric acid anchored on a surface generate different insulin assemblies and hence contrasting cellular responses.chemical science,5(11),4367-4374. |
| MLA | Wei, Weili,et al."Opposing enantiomers of tartaric acid anchored on a surface generate different insulin assemblies and hence contrasting cellular responses".chemical science 5.11(2014):4367-4374. |
入库方式： OAI收割
来源：长春应用化学研究所
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