Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy
文献类型：期刊论文
| 作者 | Bai, Jing ; Liu, Yuwei ; Jiang, Xiue |
| 刊名 | biomaterials
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:22页码:5805-5813 |
| 关键词 | GRAPHENE OXIDE NANOCOMPOSITES CANCER-THERAPY DRUG-DELIVERY NEW-GENERATION IN-SITU NANOPARTICLES PLATFORM CHEMOTHERAPY DOXORUBICIN TOXICITY |
| ISSN号 | 0142-9612 |
| 通讯作者 | jiang,xe |
| 中文摘要 | the synergistic therapy, the combination of photothermal therapy and chemotherapy, has become a potential treatment in the battles with cancer. here, we developed a synergistic therapy tool that based on cus nanopartides-decorated graphene oxide functionalized with polyethylene glycol (peg-go/cus) for cervical cancer treatment. the as-synthesized peg-go/cus nanocomposites with excellent biocompatibility was revealed to have high storage capacity for anticancer drug of doxorubicin (dox) and high photothermal conversion efficiency, and were effectively employed for the ablation of tumor. in addition, the therapeutic efficacy of dox-loaded peg-go/cus (peg-go/cus/dox) nanocomposites was evaluated in vitro and in vivo for cervical cancer therapy. in vitro cell cytotoxicity tests of peg-go/cus/dox demonstrate about 13 and 2.7-fold toxicity than peg-go/cus and free dox under 5 min irradiation with nir laser at 1.0 w/cm(2), owing to both peg-go/cus-mediated photothermal ablation and cytotoxicity of light-triggered dox release. in mouse models, mouse cervical tumor growth was found to be significantly inhibited by the chemo-photothermal effect of peg-go/cus/dox nanocomposites, resulting in effective tumor reduction. overall, compared with chemotherapy or photothermal therapy alone, the combined treatment demonstrates better therapeutic efficacy of cancer in vitro and in vivo. these findings highlight the promise of the highly versatile multifunctional nanoparticles in biomedical application. (c) 2014 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000336694700017 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50671]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Bai, Jing,Liu, Yuwei,Jiang, Xiue. Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy[J]. biomaterials,2014,35(22):5805-5813. |
| APA | Bai, Jing,Liu, Yuwei,&Jiang, Xiue.(2014).Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy.biomaterials,35(22),5805-5813. |
| MLA | Bai, Jing,et al."Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy".biomaterials 35.22(2014):5805-5813. |
入库方式： OAI收割
来源：长春应用化学研究所
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