Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI
文献类型：期刊论文
| 作者 | Cheng, Ziyong ; Dai, Yunlu ; Kang, Xiaojiao ; Li,Chunxia ; Huang,Shanshan ; Lian,Hongzhou ; Hou,Zhiyao ; Ma,Pingan ; Lin,Jun |
| 刊名 | biomaterials
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:24页码:6359-6368 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES UP-CONVERSION NANOPARTICLES DRUG-DELIVERY MAGNETIC NANOPARTICLES IN-VIVO BIOMEDICAL APPLICATIONS PHOTOTHERMAL THERAPY FACILE SYNTHESIS CONTRAST AGENTS CANCER-THERAPY |
| ISSN号 | 0142-9612 |
| 通讯作者 | ma,pa |
| 中文摘要 | a facile method for transferring hydrophobic iron oxide nanoparticles (ionps) from chloroform to aqueous solution via encapsulation of fitc-modified gelatin based on the hydrophobic-hydrophobic interaction is described in this report. due to the existence of large amount of active groups such as amine groups in gelatin, the fluorescent labeling molecules of fluorescein isothiocyanate (fitc) and platinum (iv) prodrug functionalized with carboxylic groups can be conveniently conjugated on the ionps. the nanoparticles carrying pt(iv) prodrug exhibit good anticancer activities when the pt(iv) complexes are reduced to pt(ii) in the intracellular environment, while the pure pt(iv) prodrug only presents lower cytotoxicity on cancer cells. meanwhile, fluorescence of fitc on the surface of nanoparticles was completely quenched due to the possible forster resonance energy transfer (fret) mechanism and showed a fluorescence recovery after gelatin release and detachment from ionps. therefore fitc as a fluorescence probe can be used for identification, tracking and monitoring the drug release. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000338804500021 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50673]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cheng, Ziyong,Dai, Yunlu,Kang, Xiaojiao,et al. Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI[J]. biomaterials,2014,35(24):6359-6368. |
| APA | Cheng, Ziyong.,Dai, Yunlu.,Kang, Xiaojiao.,Li,Chunxia.,Huang,Shanshan.,...&Lin,Jun.(2014).Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI.biomaterials,35(24),6359-6368. |
| MLA | Cheng, Ziyong,et al."Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI".biomaterials 35.24(2014):6359-6368. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。