Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy
文献类型：期刊论文
| 作者 | Tao, Yu ; Ju, Enguo ; Liu, Zhen ; Dong,Kai ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | biomaterials
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:24页码:6646-6656 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES MODIFIED GOLD NANORODS IN-VIVO CANCER-THERAPY DRUG-DELIVERY COMBINATION THERAPY CARBON NANOTUBES DENDRITIC CELLS BREAST-CANCER DNA |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren,js |
| 中文摘要 | new combination therapy strategy, which takes the advantages of co-delivery two or more therapeutic agents in one nanocarrier platform, has been widely used in the clinic and achieved immense popularity in cancer treatment. here, we have rationally developed a multifunctional platform using a self-assembly strategy to incorporate materials with specific functions of chemotherapeutics, hyperthermia, and especially immunotherapy, which can collectively contribute to the effective cancer treatment. we design the immunomodulatory cpg odns based platform that is conjugated with nir-responsive gold nanorods and doxorubicin for cancer therapy. the gold nanorods can be applied as the nanocarrier to simultaneously address the three kinds of treatments, which lead to a significant benefit relative to the use of each method alone. both in vitro and in vivo assays reveal that this engineered vehicle exhibits significant antitumor efficacy. our studies provide strong evidence that the aunrs-cpg-dox conjugates can be utilized as efficient antitumor agents |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000338804500048 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50674]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tao, Yu,Ju, Enguo,Liu, Zhen,et al. Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy[J]. biomaterials,2014,35(24):6646-6656. |
| APA | Tao, Yu,Ju, Enguo,Liu, Zhen,Dong,Kai,Ren,Jinsong,&Qu,Xiaogang.(2014).Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy.biomaterials,35(24),6646-6656. |
| MLA | Tao, Yu,et al."Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy".biomaterials 35.24(2014):6646-6656. |
入库方式： OAI收割
来源：长春应用化学研究所
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