DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery
文献类型：期刊论文
| 作者 | Zhou, Li ; Chen, Zhaowei ; Dong, Kai ; Yin,Meili ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | biomaterials
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:30页码:8694-8702 |
| 关键词 | PHOSPHATE NANOCOMPOSITE PARTICLES CALCIUM-PHOSPHATE HOLLOW SPHERES GENE DELIVERY NUCLEIC-ACID CANCER-CELLS TRANSFECTION NANOPROBES OXIDE METALLIZATION |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren,js |
| 中文摘要 | a dna-guided method for surface engineering of nagdf4:ce/tb hybrid nanoparticle has been proposed. in this study, the dna molecules that retained after one-pot nagdf4:ce/tb synthesis is directly utilized as biotemplate for cap heterogeneous nucleation, thus the dual-purpose function of dna is realized in the current study which could afford a new type of ph-responsive theranostic platform to enhance the therapeutic efficiency while minimizing side effects. the introduction of another layer of aptamer molecules on cap facilitated cellular uptake of the resulting nanocomposite into specific target cells via receptor-mediated endocytosis. after been taken by the target tumor cells, the nagdf4:ce/tb@cap was found to be mostly accumulated in lysosome, which facilitated the dissolving of cap coatings as non-toxic ions to initiate drug release and efficient cancer cell destruction. we envision that the hybrid nanocarrier may serve as practical and multifunctional probe for cancer therapy and the presented synthesis approach here may also benefit the preparation of many other types of multifunctional inorganic-biomolecular hybrid nanostructures based on the dna nanotechnology. (c) 2014 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000340849600023 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50675]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou, Li,Chen, Zhaowei,Dong, Kai,et al. DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery[J]. biomaterials,2014,35(30):8694-8702. |
| APA | Zhou, Li,Chen, Zhaowei,Dong, Kai,Yin,Meili,Ren,Jinsong,&Qu,Xiaogang.(2014).DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery.biomaterials,35(30),8694-8702. |
| MLA | Zhou, Li,et al."DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery".biomaterials 35.30(2014):8694-8702. |
入库方式： OAI收割
来源：长春应用化学研究所
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