A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy
文献类型：期刊论文
| 作者 | Wang, Zhenzhen ; Chen, Zhaowei ; Liu, Zhen ; Shi,Peng ; Dong,Kai ; Ju,Eenguo ; Ren,Jinsong ; Qu,Xiaogang |
| 刊名 | biomaterials
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:36页码:9678-9688 |
| 关键词 | MESOPOROUS SILICA NANOCONTAINERS INTRACELLULAR CONTROLLED-RELEASE DRUG-DELIVERY CANCER-THERAPY POLYMERIC NANOPARTICLES MAGNETIC NANOPARTICLES ACID SYSTEM DOXORUBICIN MONODISPERSE |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren,js |
| 中文摘要 | noninvasive and pinpointed intracellular drug release that responds to multiple stimulus is still a formidable challenge for cancer therapy. herein, we reported a multi-stimuli responsive platform based on drug loaded gold nanocages @ hyaluronic acid (auncs-ha) for pinpointed intracellular drug release. these well-prepared nanohybrids could specifically recognize cancer cells via ha-cd44 interactions and be efficiently endocytosed by receptor-mediated process. subsequently, the coated ha molecules could be degraded in lysosomes, resulting in the release of encapsulated drug. in addition, by taking advantage of the excellent photothermal properties, the auncs could accelerate the release of encapsulated drug and induce a higher therapeutic efficacy upon near-infrared (nir) irradiation. in vitro results confirmed that the encapsulated drug could only be pinpointedly released in intracellular environments, which permitted high therapeutic efficacy against cancer cells and minimized the side effects. importantly, as compared to that of the two therapies independently, a complete inhibition of tumor growth treated with the combination of chemotherapy and photothermal therapy was observed in vivo. taken together, our present study provides new insights into developing pinpointed, multi-stimuli responsive intracellular drug release systems for synergistic cancer therapy. (c) 2014 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000342890200012 |
| 公开日期 | 2015-03-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50676]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang, Zhenzhen,Chen, Zhaowei,Liu, Zhen,et al. A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy[J]. biomaterials,2014,35(36):9678-9688. |
| APA | Wang, Zhenzhen.,Chen, Zhaowei.,Liu, Zhen.,Shi,Peng.,Dong,Kai.,...&Qu,Xiaogang.(2014).A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy.biomaterials,35(36),9678-9688. |
| MLA | Wang, Zhenzhen,et al."A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy".biomaterials 35.36(2014):9678-9688. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。