pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers
文献类型：期刊论文
| 作者 | Tian, Huayu ; Guo, Zhaopei ; Lin, Lin ; Jiao,Zixue ; Chen,Jie ; Gao,Shiqian ; Zhu,Xiaojuan ; Chen,Xuesi |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2014 |
| 卷号 | 174期号:1页码:117-125 |
| 关键词 | GOLD NANOPARTICLES DRUG-DELIVERY EFFICIENT TRANSFECTION LIBRARY CANCER INTERNALIZATION TRANSPORT POLYPLEX MICELLES |
| ISSN号 | 0168-3659 |
| 通讯作者 | zhu,xj |
| 中文摘要 | a novel rapid ph-responssive polymer polyethylenimine-poly(l-lysine)-poly(l-glutamic acid) ( pelg) was designed as the shielding system. the zwitterionic copolypeptide pelg with negatively charged at physical ph can act as the shielding system to shield positively charged polyplexes. pelg was used to shield pei25k/dna to form ternary polyplex, the polyplex surface zeta potential can change from a negative to positive nearly ph value of 6.9. because the ph value of tumor extracellular environment is about 6.5, the positive charges on the polyplexes could be restored in tumors, which is beneficial to the electrostatic interactions between positive polyplexes and negative tumor cells, leading to high cell uptake efficiency and high transfection efficiency. (c) 2013 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329964500014 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50687]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tian, Huayu,Guo, Zhaopei,Lin, Lin,et al. pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers[J]. journal of controlled release,2014,174(1):117-125. |
| APA | Tian, Huayu.,Guo, Zhaopei.,Lin, Lin.,Jiao,Zixue.,Chen,Jie.,...&Chen,Xuesi.(2014).pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers.journal of controlled release,174(1),117-125. |
| MLA | Tian, Huayu,et al."pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers".journal of controlled release 174.1(2014):117-125. |
入库方式： OAI收割
来源：长春应用化学研究所
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