Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel
文献类型：期刊论文
| 作者 | Lv, Shixian ; Tang, Zhaohui ; Zhang, Dawei ; Song,Wantong ; Li,Mingqiang ; Lin,Jian ; Liu,Huaiyu ; Chen,Xuesi |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2014 |
| 卷号 | 194期号:12页码:220-227 |
| 关键词 | CELL LUNG-CANCER BLOCK-COPOLYMER IN-VIVO EXTRACELLULAR PH MICELLES NANOPARTICLES DOXORUBICIN PLATFORM SYSTEM TUMORS |
| ISSN号 | 0168-3659 |
| 通讯作者 | chen,xs |
| 中文摘要 | the synthesis of polymer-drug conjugate (pdc) capable of convenient preparation and controlled release of therapeutic agents is still an urgent requirement in drug delivery field. herein, we develop a novel anti-cancer pdc engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (ptx) with redox and ph dual sensitive behaviors. a simple polymer, 3,3'-dithiodipropionic acid functionalized poly(ethylene glycol)-b-poly(l-lysine) (mpeg-b-p(ll-dtpa)), was synthesized and ptx was directly conjugated to the carboxyl groups of mpeg-b-p(ll-dtpa) to obtain the disulfide-containing polymer-ptx conjugate (p(l-ss-ptx)). another structural similar polymer-ptx conjugate without disulfide bonds (p(l-ptx)) was also prepared to verify the function of disulfide linkages. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000344229800022 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50689]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lv, Shixian,Tang, Zhaohui,Zhang, Dawei,et al. Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel[J]. journal of controlled release,2014,194(12):220-227. |
| APA | Lv, Shixian.,Tang, Zhaohui.,Zhang, Dawei.,Song,Wantong.,Li,Mingqiang.,...&Chen,Xuesi.(2014).Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.journal of controlled release,194(12),220-227. |
| MLA | Lv, Shixian,et al."Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel".journal of controlled release 194.12(2014):220-227. |
入库方式： OAI收割
来源：长春应用化学研究所
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