Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China
文献类型：期刊论文
| 作者 | Li, Jian ; Ren, Shujuan ; Han, Shaolun ; Lei, Bingli ; Li, Na |
| 刊名 | ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 67期号:1页码:68-77 |
| ISSN号 | 0090-4341 |
| 中文摘要 | Thyroid hormone (TH) has long been known to be essential for normal brain development in both humans and animals, and increasing evidence suggests that environmental components may disrupt TH signaling. In the present study, two-hybrid yeast bioassay and chemical analysis were used to evaluate and identify thyroid-receptor (TR) disruptors in water from the Guanting Reservoir, Beijing, China. Modified yeast bioassay showed that the water samples could affect TH signaling. The bioassay-derived amiodarone hydrochloride equivalents ranged from 33.8 +/- A 3.3 to 308.5 +/- A 31.8 A mu g/L. Solid-phase extraction was used to separate the organic extracts, which were subjected to bioassay and chemical analysis. The organic extracts significantly antagonized the TR, which accounted for > 86.0 % of the total effects. Thus, organic extracts may play a major role in the TR-disruption activity of the water. Phenols, organochlorine pesticides, and phthalate esters were detected in the organic extracts. Chemical analysis and toxic-equivalent calculation showed that a major cause of the TR antagonism of the water was dibutyl phthalate (80.1 to 122.7 %). |
| WOS记录号 | WOS:000336983300008 |
| 公开日期 | 2015-03-23 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9172]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Jian,Ren, Shujuan,Han, Shaolun,et al. Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2014,67(1):68-77. |
| APA | Li, Jian,Ren, Shujuan,Han, Shaolun,Lei, Bingli,&Li, Na.(2014).Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,67(1),68-77. |
| MLA | Li, Jian,et al."Identification of Thyroid-Receptor Antagonists in Water from the Guanting Reservoir, Beijing, China".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 67.1(2014):68-77. |
入库方式： OAI收割
来源：生态环境研究中心
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