Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China
文献类型：期刊论文
| 作者 | Li, Jian ; Li, Morui ; Ren, Shujuan ; Feng, Chenglian ; Li, Na |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2014 |
| 卷号 | 274期号:1页码:191-197 |
| 关键词 | In vitro bioassay Thyroid receptor Thyroid disrupting chemicals Sediment |
| ISSN号 | 0304-3894 |
| 中文摘要 | In the present study, yeast bioassays were used to evaluate and characterize the thyroid receptor (TR) disrupting activities of the organic extracts and elutriates of the sediments from the Guanting Reservoir, Beijing, China. An accelerated solvent extraction was used to separate the organic extracts, which were subjected to a yeast bioassay. The organic extracts could affect thyroid hormone signaling by decreasing the binding of the thyroid hormone. The TR antagonistic activity equivalents (TEQ(bio)) referring to amiodarone hydrochloride were calculated and the observed TEQ(bio-organic) (extracts) ranged from 25.4 +/- 3.7 to 176.9 +/- 18.0 mu g/g. Elutriate toxicity tests using the modified yeast bioassay revealed that the elutriates also significantly antagonized the TR, with the TEQ(bio-elutriates) ranging from N.D. to 7.8 +/- 0.8 mu g/L. To characterize the toxic compounds, elutriates were extracted by using a C18 cartridge or treated with ethylenediaminetetraacetic acid (EDTA, 30 mg/L). The results suggested that the addition of EDTA eliminated over 74.3% of the total effects, and the chemical analysis revealed that heavy metals, some of which exhibited TR disrupting potency, for example Zn and Cd, were detectable with higher concentrations in the elutriates. Thus, the cause(s) of toxicity in the elutriate appear to be partly related to the heavy metals. (C) 2014 Elsevier B.V. All rights reserved. |
| 公开日期 | 2015-03-23 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9242]  |
| 专题 | 生态环境研究中心_城市与区域生态国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Jian,Li, Morui,Ren, Shujuan,et al. Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China[J]. JOURNAL OF HAZARDOUS MATERIALS,2014,274(1):191-197. |
| APA | Li, Jian,Li, Morui,Ren, Shujuan,Feng, Chenglian,&Li, Na.(2014).Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China.JOURNAL OF HAZARDOUS MATERIALS,274(1),191-197. |
| MLA | Li, Jian,et al."Thyroid hormone disrupting activities of sediment from the Guanting Reservoir, Beijing, China".JOURNAL OF HAZARDOUS MATERIALS 274.1(2014):191-197. |
入库方式： OAI收割
来源：生态环境研究中心
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