6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-C-14] 6:2 fluorotelomer alcohol
文献类型：期刊论文
| 作者 | Ruan, Ting ; Sulecki, Lisa M. ; Wolstenholme, Barry W. ; Jiang, Guibin ; Wang, Ning ; Buck, Robert C. |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2014 |
| 卷号 | 112期号:1页码:34-41 |
| 关键词 | 6:2 Fluorotelomer iodide (6:2 FTI) 6:2 Fluorotelomer alcohol (6:2 FTOH) 5:3 Acid Perfluorocarboxylic acids (PFCAs) In vitro metabolism Rat liver microsomes |
| ISSN号 | 0045-6535 |
| 中文摘要 | 6:2 Fluorotelomer iodide [6:2 FTI, F(CF2)(6)CH2CH2I] is the industrial raw material used to manufacture 6:2 fluorotelomer alcohol [6:2 FTOH, F(CF2)(6)CH2CH2OH] and 6:2 FTOH-based products. During its manufacture and industrial use, workers may be exposed to via oral, dermal or inhalation of 6:2 FTI. Therefore it is useful to understand how 6:2 HI may be metabolized and into what transformation products. 6:2 FTI in vitro rat liver microsomal metabolism was explored for the first time to compare its biotransformation potential with that of [1,2-C-14] 6:2 FTOH [F(CF2)(6)(CH2CH2OH)-C-14-C-14]. 6:2 FTI and 6:2 FTOH metabolite yields were determined in closed-bottle systems using Sprague Dawley and Wistar Han rat microsomes after incubation at 37 C for up to 6 h with NADPH (reduced form of nicotinamide adenine dinucleotide phosphate)-addition and NADPH-regenerating systems, respectively. 5:3 acid [F(CF2)(5)CH2CH2COOH] was the most abundant metabolite for 6:2 FTI (3.3-6.3 mol%) and 6:2 FTOH (9-12 mol%). Perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA), and perfluorohexanoic acid (PFHxA) in sum accounted for 1.3-2.2 mol% from 6:2 FTI and 2.7-4.4 mol% from 6:2 FTOH biotransformation. Perfluoroheptanoic acid (PFHpA) accounted for 0.14-0.36 mol% from 6:2 FTI but only 0.01-0.06 mol% from 6:2 FTOH biotransformation. These results suggest that mammalian systems exposed to 6:2 FTI or 6:2 FTOH would form 5:3 acid, PFBA, PFPeA, PFHxA as the primary stable metabolites, whereas more PFHpA would be expected from 6:2 FTI biotransformation. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000340688300005 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9301]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ruan, Ting,Sulecki, Lisa M.,Wolstenholme, Barry W.,et al. 6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-C-14] 6:2 fluorotelomer alcohol[J]. CHEMOSPHERE,2014,112(1):34-41. |
| APA | Ruan, Ting,Sulecki, Lisa M.,Wolstenholme, Barry W.,Jiang, Guibin,Wang, Ning,&Buck, Robert C..(2014).6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-C-14] 6:2 fluorotelomer alcohol.CHEMOSPHERE,112(1),34-41. |
| MLA | Ruan, Ting,et al."6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-C-14] 6:2 fluorotelomer alcohol".CHEMOSPHERE 112.1(2014):34-41. |
入库方式： OAI收割
来源：生态环境研究中心
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