Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin
文献类型：期刊论文
| 作者 | Shan, Qiuli ; Wang, Jing ; Huang, Fengchen ; Lv, Xiaowen ; Ma, Min ; Du, Yuguo |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 276期号:2页码:136-146 |
| 关键词 | PCBs TCDD Atherosclerosis PF4 MCP-1 RIG-I |
| ISSN号 | 0041-008X |
| 中文摘要 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants found as complex mixtures in the environment throughout the world. Therefore, humans are ubiquitously and simultaneously exposed to TCDD and PCBs. TCDD and PCBs alone have been linked to atherosclerosis. However, the effects of interactions or synergism between TCDD and PCBs on atherogenesis are unknown. We investigated the possible enhanced atherogenesis by co-exposure to TCDD and PCBs and the potential mechanism(s) involved in this enhancement Male ApoE(-/-) mice were exposed to TCDD (15 mu g/kg) and Aroclor1254 (55 mg/kg, a representative mixture of PCBs) alone or in combination by intraperitoneal injection four times over six weeks of duration. Our results showed that mice exposed to TCDD alone, but not Aroclor1254 alone, developed atherosclerotic lesions. Moreover, we found that atherosclerotic disease was exacerbated to the greatest extent in mice co-exposed to TCDD and Aroclor1254. The enhanced lesions correlated with several pro-atherogenic changes, including a marked increase in the accumulation of the platelet-derived chemokine PF4, and the expression of the proinflammatory cytokine MCP-1 and the critical immunity gene-RIG-I. Our data demonstrated that co-exposure to TCDD and Aroclor1254 markedly enhanced atherogenesis in ApoE(-/-) mice. Significantly, our observations suggest that combined exposure to TCDD and PCBs may be a greater cardiovascular health risk than previously anticipated from individual studies. (C) 2014 Elsevier Inc All rights reserved. |
| WOS记录号 | WOS:000334821900007 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9318]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Shan, Qiuli,Wang, Jing,Huang, Fengchen,et al. Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2014,276(2):136-146. |
| APA | Shan, Qiuli,Wang, Jing,Huang, Fengchen,Lv, Xiaowen,Ma, Min,&Du, Yuguo.(2014).Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin.TOXICOLOGY AND APPLIED PHARMACOLOGY,276(2),136-146. |
| MLA | Shan, Qiuli,et al."Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin".TOXICOLOGY AND APPLIED PHARMACOLOGY 276.2(2014):136-146. |
入库方式： OAI收割
来源：生态环境研究中心
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