Disordered hepcidin-ferroportin signaling promotes breast cancer growth
文献类型：期刊论文
| 作者 | Zhang, Shuping ; Chen, Yue ; Guo, Wenli ; Yuan, Lin ; Zhang, Daoqiang ; Xu, Yong ; Nemeth, Elizabeta ; Ganz, Tomas ; Liu, Sijin |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:11页码:2539-2550 |
| ISSN号 | 0898-6568 |
| 关键词 | Iron Hepcidin Ferroportin Breast cancer |
| 中文摘要 | Iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including cancers. Burgeoning evidence indicates that the central signaling of iron homeostasis, the hepcidin ferroportin axis, is misregulated in cancers. Nonetheless, the mechanisms of misregulated expression of iron-related genes along this signaling in cancers remain largely unknown. In the current study, we found increased levels of serum hepcidin in breast cancer patients. Reduction of hepatic hepcidin through administration of heparin restrained tumorigenic properties of breast tumor cells. Mechanistic investigation revealed that increased iron, bone morphogenetic protein-6 (BMP6) and interleukin-6 (IL-6) jointly promoted the synthesis of hepatic hepcidin. Tumor hepcidin expression was marginally increased in breast tumors relative to adjacent tissues. In contrast, tumor ferroportin concentration was greatly reduced in breast tumors, especially in malignant tumors, compared to adjacent tissues. Elevation of ferroportin concentration inhibited cell proliferation in vitro and in vivo by knocking down tumor hepcidin expression. Additionally, increased IL-6 was demonstrated to jointly enhance the tumorigenic effects of iron through enforcing cell growth. Our combined data overall deciphered the machinery that altered the hepcidin ferroportin signaling in breast cancers. Thus, targeting the hepcidin ferroportin signaling would represent a promising therapeutics to restrain breast cancer growth. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS记录号 | WOS:000342717400026 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9344]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Shuping,Chen, Yue,Guo, Wenli,et al. Disordered hepcidin-ferroportin signaling promotes breast cancer growth[J]. CELLULAR SIGNALLING,2014,26(11):2539-2550. |
| APA | Zhang, Shuping.,Chen, Yue.,Guo, Wenli.,Yuan, Lin.,Zhang, Daoqiang.,...&Liu, Sijin.(2014).Disordered hepcidin-ferroportin signaling promotes breast cancer growth.CELLULAR SIGNALLING,26(11),2539-2550. |
| MLA | Zhang, Shuping,et al."Disordered hepcidin-ferroportin signaling promotes breast cancer growth".CELLULAR SIGNALLING 26.11(2014):2539-2550. |
入库方式： OAI收割
来源：生态环境研究中心
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