Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload
文献类型：期刊论文
| 作者 | Sun, Li ; Guo, Wenli ; Yin, Chunyang ; Zhang, Shuping ; Qu, Guangbo ; Hou, Yanli ; Rong, Haiqin ; Ji, Hong ; Liu, Sijin |
| 刊名 | GENE
 |
| 出版日期 | 2014 |
| 卷号 | 543期号:1页码:161-165 |
| 关键词 | Hepcidin deficiency Iron overload Bone resorption Bone strength |
| ISSN号 | 0378-1119 |
| 中文摘要 | Osteoporosis is one of the leading disorders among aged people. Bone loss results from a number of physiological alterations, such as estrogen decline and aging. Meanwhile, iron overload has been recognized as a risk factor for bone loss. Systemic iron homeostasis is fundamentally governed by the hepcidin-ferroportin regulatory axis, where hepcidin is the key regulator. Hepcidin deficiency could induce a few disorders, of which iron overload is the most representative phenotype. However, there was little investigation of the effects of hepcidin deficiency on bone metabolism. To this end, hepcidin-deficient (Hamp1(-/-)) mice were employed to address this issue. Our results revealed that significant iron overload was induced in Hamp1(-/-) mice. Importantly, significant decreases of maximal loading and maximal bending stress were found in Hamp1(-/-) mice relative to wildtype (WT) mice. Moreover, the levels of the C-telopeptide of type I collagen (CTX-1) increased in Hamp1(-/-) mice. Therefore, hepcidin deficiency resulted in a marked reduction of bone load-bearing capacity likely through enhancing bone resorption, suggesting a direct correlation between hepcidin deficiency and bone loss Targeting hepcidin or the pathway it modulates may thus represent a therapeutic for osteopenia or osteoporosis. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000336355500022 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9379]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Li,Guo, Wenli,Yin, Chunyang,et al. Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload[J]. GENE,2014,543(1):161-165. |
| APA | Sun, Li.,Guo, Wenli.,Yin, Chunyang.,Zhang, Shuping.,Qu, Guangbo.,...&Liu, Sijin.(2014).Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload.GENE,543(1),161-165. |
| MLA | Sun, Li,et al."Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload".GENE 543.1(2014):161-165. |
入库方式： OAI收割
来源：生态环境研究中心
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