HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis
文献类型：期刊论文
| 作者 | Zhang, Changwen ; Yin, Chunyang ; Wang, Lei ; Zhang, Shuping ; Qian, Yi ; Ma, Juan ; Zhang, Zhihong ; Xu, Yong ; Liu, Sijin |
| 刊名 | MOLECULAR CANCER RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:4页码:583-594 |
| ISSN号 | 1541-7786 |
| 中文摘要 | Activation of c-Myc plays a decisive role in the development of many human cancers. As a transcription factor, c-Myc facilitates cell growth and proliferation by directly transcribing a multitude of targets, including rRNAs and ribosome proteins. However, how to elucidate the deregulation of rRNAs and ribosome proteins driven by c-Myc in cancer remains a significant challenge and thus warrants close investigation. In this report, a crucial role for the HSPC111 (NOP16) multiprotein complex in governing ribosomal biogenesis and tumor growth was determined. It was discovered that enhanced HSPC111 expression paralleled the upregulation of c-Myc and was directly regulated by c-Myc in breast cancer cells. Knockdown of HSPC111 dramatically reduced the occurrence of tumorigenesis in vivo, and largely restrained tumor cell growth in vitro and in vivo. In stark contrast, HSPC111 overexpression significantly promoted tumor cell growth. Biochemically, it was demonstrated that RNA 3'-phosphate cyclase (RTCD1/RTCA) interacted with HSPC111, and RTCD1 was involved in the HSPC111 multiprotein complex in regulating rRNA production and ribosomal biogenesis. Moreover, HSPC111 and RTCD1 synergistically modulated cell growth and cellular size through commanding rRNA synthesis and ribosome assembly coupled to protein production. Finally, overall survival analysis revealed that concomitant upregulation of HSPC111 and RTCD1 correlated with the worst prognosis in a breast cancer cohort. Implications: Inhibition of HSPC111-dependent ribosomal biosynthesis and protein synthesis is a promising therapeutic strategy to diminish breast cancer tumor progression. (C) 2014 AACR. |
| WOS记录号 | WOS:000334583900011 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9383]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Changwen,Yin, Chunyang,Wang, Lei,et al. HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis[J]. MOLECULAR CANCER RESEARCH,2014,12(4):583-594. |
| APA | Zhang, Changwen.,Yin, Chunyang.,Wang, Lei.,Zhang, Shuping.,Qian, Yi.,...&Liu, Sijin.(2014).HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis.MOLECULAR CANCER RESEARCH,12(4),583-594. |
| MLA | Zhang, Changwen,et al."HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis".MOLECULAR CANCER RESEARCH 12.4(2014):583-594. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。