Photoelectrochemical Sensors for the Detection of DNA Damage
文献类型：期刊论文
| 作者 | Wu Yiping ; Guo Lianghong |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:1页码:1-9 |
| 关键词 | DNA sensor photoelectrochemical detection DNA damage toxicity screening |
| ISSN号 | 1005-281X |
| 中文摘要 | DNA is a kind of genetic material that encodes the genetic instructions used in the development and functioning of all known living organisms and many viruses. DNA damage occurs frequently in organisms. Some endogenous and exogenous chemicals have been found to induce structural damages to nuclear DNA by base oxidation or modification. If unrepaired, these damaged DNA may lead to gene mutation and even tumor generation. Due to their short response time, high sensitivity, low cost and ease of miniaturization, electrochemical DNA sensors are well qualified for the rapid screening of industrial and environmental chemicals for their potential geno-toxicity. This review article first introduces briefly the types and working mechanisms of current electrochemical DNA sensors. Then it describes in more detail the work on electrochemical and photoelectrochemical sensors for the detection of DNA damage, based largely on the work of our own laboratory, including general type sensors for the rapid screening of industrial and environmental chemicals with potential geno-toxicity,, as well as specific type sensors for the identification and quantification of DNA damage products such as 8-oxodGuo and methylated DNA bases. In the end, the existing problems and future research directions of the DNA damage electrochemical sensors are discussed. |
| WOS记录号 | WOS:000330554500001 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9425]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu Yiping,Guo Lianghong. Photoelectrochemical Sensors for the Detection of DNA Damage[J]. PROGRESS IN CHEMISTRY,2014,26(1):1-9. |
| APA | Wu Yiping,&Guo Lianghong.(2014).Photoelectrochemical Sensors for the Detection of DNA Damage.PROGRESS IN CHEMISTRY,26(1),1-9. |
| MLA | Wu Yiping,et al."Photoelectrochemical Sensors for the Detection of DNA Damage".PROGRESS IN CHEMISTRY 26.1(2014):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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